Molecular chiral discrimination through symmetry-breaking spin dynamics

Le résumé fourni par la source

Molecular chirality plays a crucial role in physics, chemistry, life sciences and pharmacology. Nowadays, the chiral discrimination and control at the single-molecule level is urgently needed to reveal the origin of the chirality-relevant phenomena by recovering the information disturbed by the ensemble averaging. The method of magnetic resonance (MR), as one of powerful tools for structure analysis, is blind to the molecular chirality in the absence of a chiral reagent. Here we propose and experimentally demonstrate a direct MR-based method for determining the chirality at the single-molecule level through constructing the symmetry-breaking dynamics of nearby nuclear spins. In principle, the mirror asymmetry of two enantiomers in real space is manifested by breaking the joint symmetry of the mirror reflection and time reversal in spin space under spin dynamics. Experimentally, two enantiomers are indistinguishable from the dynamics of strongly-coupled but unpolarized nuclear spins, but diverge evidently in the dynamical results that break the field-inversion symmetry after spins are polarized. Our method and results will benefit the study of chirality-induced properties in the fields of chemistry and biology.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.