Psychological, Social, and Ethical Implications of Population-Based Genetic Testing among Adults: A Systematic Scoping Review with a Focus on Cancer

Le résumé fourni par la source

Rationale: Population-based genetic testing (PBGT), which involves offering genetic testing unselectively to the public, has the potential to upscale the benefits of precision prevention of inherited diseases. However, for such a large-scale screening program to be successfully implemented in the public setting, it is important to evaluate the psychological implications of PBGT as well as setting up standards to make sure that the program is socially and ethically responsible. To this end, we propose a narrative literature review examining existing research on psychological, social, and ethical influences in the context of unselective genetic testing for cancer screening and prevention. Review objectives: This review aims to identify which psychological, social, and ethical aspects of PBGT have been assessed, evaluate the quality of existing evidence, and highlight research gaps to facilitate the future design and implementation of PBGT.

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