Beyond antibodies: Emerging roles of B cells in gastrointestinal inflammation and disease

Le résumé fourni par la source

B cells play a crucial role in maintaining immune homeostasis at mucosal surfaces, including those of the gastrointestinal (GI) tract. Perturbed humoral immunity and antibody-mediated functions of B cells are well described in patients with chronic GI inflammatory diseases. However, our understanding of antibody-independent B cell functions such as antigen presentation, immunoregulatory cytokine production and tissue remodeling are more limited. Comprehensively defining the immunobiology of B cells beyond humoral immunity during GI inflammation will improve our ability to develop effective, targeted treatments that modulate B cell pro- versus anti-inflammatory activity in the clinical management of GI inflammatory diseases. In this review, we discuss the emerging roles of B cells using antibody-independent mechanisms to maintain intestinal homeostasis, and how this evolves to B cells becoming active players in immunopathology underlying GI inflammatory conditions and specific GI cancers.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.