Optimization of hydrolysates from amine-based biomass deconstruction through nutrient supplementation for enhanced microbial bioprocess performance

Le résumé fourni par la source

The efficient use of lignocellulosic hydrolysates as feedstocks in industrial-scale fermentations is essential for sustainable production of biofuels and biochemicals.This study focuses on optimizing the usability of plant-based hydrolysates derived from amine-based pretreatment methods.A key challenge lies in the variable nutrient composition of these hydrolysates and their incomplete support of microbial growth and productivity.We employed a high-throughput approach to systematically analyze and enhance the nutritional profile of the hydrolysate.Multifactorial screening experiments were conducted at small scale to assess the impact of various nutrient supplements on microbial growth dynamics and product yields in Rhodosporidium toruloides.Through iterative optimization, we identified cost-effective supplementation strategies that significantly improve sugar utilization and overall process productivity.The results underscore the potential of DoE-driven process development in enabling economically viable and scalable bioconversion of lignocellulosic feedstocks.

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