Pancreatic mucinous cystic neoplasms in a young female: A case report
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
RATIONALE: Pancreatic cystic neoplasms (PCNs) encompass a wide spectrum of disease from benign to malignant. Mucinous cystic neoplasms (MCNs) are the second most common PCNs, typically occurring as solitary masses in the pancreatic body or tail of middle-aged women. They are characterized by elevated cyst fluid carcinoembryonic antigen (CEA) and low amylase due to lack of ductal communication. While MCNs have malignant potential, and lesions >3 cm are higher risk, size alone is not an absolute predictor of malignancy. We present a rare case of an exceptionally large, yet benign, PCN in a 24-year-old female, with a paradoxical cyst fluid biomarker profile. PATIENT CONCERNS: A 24-year-old female with a known pancreatic tail cystic mass presented with acute-on-chronic abdominal pain, nausea, and vomiting - endorsing epigastric pain for the past year. The lesion was initially identified in January 2024 on imaging, measuring 11.7 × 10.2 × 8.1 cm, with prior non-diagnostic cytology. DIAGNOSES: Abdominal magnetic resonance imaging with cholangiopancreatography demonstrated a complex cystic mass measuring 8.4 × 12.8 × 16 cm abutting the pancreas with moderate volume ascites. Endoscopic ultrasound (EUS)-guided fine-needle biopsy revealed a 12 cm complex mass encompassing the distal pancreas. Surgical pathology confirmed a noninvasive, low-grade MCN with no evidence of high-grade dysplasia. INTERVENTIONS: Given the significant symptom burden and cyst size, she underwent distal pancreatectomy with splenectomy; the cystic mass was adherent to the splenic vessels at the hilum, precluding a spleen-sparing procedure. OUTCOMES: Pathology revealed a 14 × 11 × 7 cm multilocular cystic mass consistent with a benign, noninvasive, low-grade MCN. The patient had an uncomplicated post-operative course and is following with outpatient providers. LESSONS: This case highlights the limitations of cyst size as a predictor of malignancy in MCN. Further, there is a possibility of discordant cyst fluid biomarkers such as low CEA and high amylase as opposed to the inverse, as seen here, which may reflect sample heterogeneity, partial ductal communication, or mixed lesions. This case therefore emphasizes the importance of integrating imaging, cyst fluid biomarkers, histopathology, and molecular testing together for accurate classification and individualized management of PCNs.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Pancreatic mucinous cystic neoplasms in a young female: A case report
- Date Crossref
- 24/07/2026
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Dartmouth–Hitchcock Medical Center pays non établi dans la noticeÉtablissement de santé
-
Hackensack University Medical Center Department of Pathology pays non établi dans la noticeÉtablissement de santé
-
Hackensack Meridian Health pays non établi dans la noticeÉtablissement de santé
-
Albert Einstein College of Medicine Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Montefiore Medical Center pays non établi dans la noticeÉtablissement de santé
-
Icahn School of Medicine at Mount Sinai Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Illinois College pays non établi dans la noticeUniversité ou école supérieure
-
University of Illinois Chicago pays non établi dans la noticeUniversité ou école supérieure
-
Hackensack Meridian School of Medicine Department of Gastroenterology pays non établi dans la noticeUniversité ou école supérieure
-
Geisel School of Medicine at Dartmouth Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
-
Retzky College of Pharmacy University of Illinois pays non établi dans la noticeUniversité ou école supérieure
-
Thomas J. Long School of Pharmacy pays non établi dans la noticeUniversité ou école supérieure
Dartmouth–Hitchcock Medical Center, Department of Pathology — Hackensack University Medical Center et Hackensack Meridian Health, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.