Fetal Heart Rate Changes in Chorioamnionitis

Le résumé fourni par la source

Chorioamnionitis (inflammation of the chorion and amnion) is a fetal disease, and the observed fetal heart rate (FHR) changes reflect the severity of infection in the fetal compartment. Transplacental passage of maternal infection (bacteria, their toxins and inflammatory cytokines) usually commences with the onset of maternal symptoms and signs (maternal tachycardia, pyrexia, being unwell), followed by the onset of a reactive fetal tachycardia (>10% increase in the baseline FHR as compared to the previously recorded baseline). The CTG trace will show changes in the FHR corresponding to the severity of fetal infections. Recent studies have shown good correlation between CTG features suggestive of chorioamnionitis as per physiological CTG interpretation and histopathological findings in the placenta, as well as interleukin-6 (IL-6) levels in the umbilical cord at birth. Experimental animal studies have confirmed that in the presence of fetal inflammatory cytokines or bacterial toxins, if there is a superimposed hypoxic stress, there is a significant increase in the risk of neurological injury.

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