Extracorporeal membrane oxygenation may prevent preterm cerebral atrophy in survivors of acute respiratory distress syndrome: a pilot trial
Rattachement africain : de. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Individuals who survive acute respiratory distress syndrome (ARDS) often face prolonged cognitive impairments. Comparable consequences have been observed in chronic hypoxic conditions, like COPD and obstructive sleep apnea syndrome, which have been linked to reduced gray matter volume. We hypothesized that ARDS patients display similar cerebral findings, but those treated with extracorporeal membrane oxygenation (ECMO) show greater structural brain alterations than those treated conservatively, reflecting the severity of hypoxemia. METHODS: Eighteen ARDS survivors, seven conservatively treated (ARDS-conv), and eleven treated with ECMO (ARDS-ECMO) were studied and compared with healthy controls. Structural magnetic resonance imaging (MRI) was analyzed using voxel-based morphometry (VBM). Total intracranial volume (TIV), gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) volumes were quantified and compared between groups. RESULTS: ARDS patients had lower TIV than healthy controls (1516.50 mL [95% CI 1380.85-1618.72] vs. 1664.07 mL [95% CI 1558.41-1776.06], P=0.008). While intracranial volumes of GM, WM, and CSF were not different between ARDS-conv and healthy controls, CSF volume of ARDS-ECMO was lower than in healthy controls, while GM and WM were comparable. Compared to ARDS-ECMO, ARDS-conv had lower GM volumes (ARDS-conv 37.9% [95% CI 36.3-39.2] vs. ARDS-ECMO 41.4% [95% CI 39.9-43.8]; P=0.036), WM and CSF were comparable. VBM also revealed distinct clusters of reduced GM in ARDS-conv patients compared to healthy controls (TFCE, FWE-corrected P<0.05). CONCLUSIONS: ARDS survivors exhibit structural brain changes suggestive of hypoxia-related injury. ECMO treatment may mitigate gray matter loss, supporting early initiation of ECMO in severe ARDS to reduce long-term neurological sequelae. Extracorporeal membrane oxygenation may prevent preterm cerebral atrophy in survivors of acute respiratory distress syndrome: a pilot trial.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Extracorporeal membrane oxygenation may prevent preterm cerebral atrophy in survivors of acute respiratory distress syndrome: a pilot trial
- Date Crossref
- 01/07/2026
- Éditeur
- Edizioni Minerva Medica
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
-
Universitätsmedizin Göttingen pays non établi dans la noticeÉtablissement de santé
-
University of Göttingen Department of Anesthesiology pays non établi dans la noticeUniversité ou école supérieure
-
Theologische Fakultät Fulda pays non établi dans la noticeUniversité ou école supérieure
-
Klinikum Fulda pays non établi dans la noticeÉtablissement de santé
-
University Hospital Regensburg pays non établi dans la noticeÉtablissement de santé
-
Jena University Hospital pays non établi dans la noticeÉtablissement de santé
-
Clinic for Diagnostic and Interventional Neuroradiology pays non établi dans la noticeÉtablissement de santé
-
Regensburg University Hospital Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
-
Center for Intervention and Research on Adaptive and Maladaptive Brain Circuits Underlying Mental Health (C-I-R-C) pays non établi dans la noticeInstitution
-
University Hospital Jena Departments of Neurology pays non établi dans la noticeUniversité ou école supérieure
-
German Center for Mental Health (DZPG) pays non établi dans la noticeInstitution
Universitätsmedizin Göttingen, Department of Anesthesiology — University of Göttingen et Theologische Fakultät Fulda, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.