MPRA processed data: Oligodendroglia as functional effectors of Multiple Sclerosis risk Single Nucleotide Polymorphisms

Le résumé fourni par la source

Processed data files from MS risk SNPs in hOPCs and Bcells in massive parallel reporter assays (MPRA) from Carlström et al. A bug in MRPAflow mpranalyze function swaped counts between samples leading to some errors. See explanation here, https://github.com/shendurelab/MPRAflow/pull/87 . In the current version, RNA and DNA counts tables for hOPCs, Bcells in all conditions have been updated, now as v2, with the correct counts. Following files remain the same from previous version: MPRA1 CRS design fasta: CRS_FINAL221208_wo_overhangs_corrected.fa MPRA1 CRS labels (FWD/REV/controls) : CRS_design_label_nooverhangs_final.tsv MPRA1 CRS association: assoc_basic_NoOver_P28515_1001_mapq_filtered_coords_to_barcodes.pickle MPRA2 CRS design fasta: GCB_CRS_order_noverhang_KC_030924_corrected.fa MPRA2 CRS labels (FWD/REV/controls) : GCB_CRS_order_noverhang_KC_030924_final.tsv MPRA2 CRS association: assoc_hOPC_250624_mapq1_filtered_coords_to_barcodes.pickle Updated files with correct RNA/DNA counts: MPRA1 Counts tables and metadata for hOPC vs Bcell analysis: MPRA1_hOPCBcell_RNADNA_counts_metadata_v2.tar.gz MPRA1 Counts tables and metadata for hOPC Ctrl vs IFN analysis: MPRA1_hOPC_CtrlIFN_RNADNA_counts_metadata_v2.tar.gz MPRA2 Counts tables and metadata for hOPC Ctrl vs IFN analysis: MPRA2_hOPC_CtrlIFN_RNADNA_counts_metadata_v2.tar.gz MPRA1 Allele pairs comparisons count tables and metadata : MPRA1_hOPCCtrl_allelicCOMPPairs_counts_annot_v2.tar.gz

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.