The Association of Interstitial Fibrosis and Ki67 Marker Expression in Papillary Thyroid Carcinoma with Histopathological Findings and Prognosis of Total Thyroidectomy

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Background: Interstitial fibrosis has been increasingly recognized as a histopathological feature with potential prognostic significance in papillary thyroid carcinoma (PTC). Ki67 expression has also been proposed as a prognostic marker in such patients. We investigated the extent of interstitial fibrosis and Ki67 expression in papillary thyroid carcinoma and its relationship with clinical and histopathological findings of the tumor, as well as prognosis of total thyroidectomy. Methods: This cross-sectional study was performed on 96 histological specimens obtained from patients with papillary thyroid carcinoma who had undergone total thyroidectomy. The extent of interstitial fibrosis of the tumor was examined in H&E-stained slides. The sections obtained were subjected to immunohistochemical staining with Ki67 monoclonal antibody to evaluate the expression of this marker. Results: Interstitial fibrosis did not have a significant relationship with tumor size, nor with the extent of tumor spread to surrounding tissues, as to lymph nodes or the vascular system. Percentage of interstitial fibrosis was not able to predict the outcomes after carcinoma surgery, such as patient mortality or tumor recurrence. A significant relationship was observed between Ki67 expression and involvement of the lymph nodes in the tumor area. The tracking of Ki67 expression could not predict the prognosis after surgery such as tumor recurrence or patient mortality. Conclusions: The expression of Ki67 is related to lymph node involvement in PTC. No significant relationship was observed between tumor biological characteristics and the percentage of interstitial fibrosis. The expression of these two markers cannot predict tumor recurrence and mortality.

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