Programmable immune activation and antitumor efficacy enabled by spatially encoded biomimetic framework nucleic acids

Résumé fourni par la source

T cell-mediated immune responses. In tumor-bearing models, this strategy further enhances immune cell infiltration and reshapes the tumor immune microenvironment, resulting in pronounced tumor suppression and improved survival outcomes. Mechanistically, these effects are attributed to a "spatial encoding-driven receptor clustering mechanism," which mimics the multivalent ligand organization of natural pathogens to promote immune activation. Collectively, this study introduces a structure-information-driven biomimetic immunomodulation strategy, offering a new design paradigm for the development of efficient and safe nanovaccines and immunotherapeutic materials.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.