Digital Phenotyping of Lifestyle Profiles and Mental Well-Being in German Adults: Prospective Longitudinal Cohort Study

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Abstract Background Digital phenotyping uses passively collected smartphone-sensing data to characterize everyday behavior in naturalistic settings, and has become an important approach for studying mental well-being. Most previous studies have examined associations between individual sensing variables and mental health. However, mental well-being is likely reflected not by isolated behaviors but by combinations of co-occurring daily behaviors that together form lifestyles. Person-centered approaches capable of identifying these behavioral configurations may, therefore, provide more interpretable digital phenotypes; yet, such approaches have rarely been applied to passive smartphone-sensing data. Objective This study aimed to examine whether smartphone-captured behavioral and environmental data could be used to derive interpretable day-level and person-level lifestyle profiles, and whether person-level profiles were associated with mental well-being. We also tested whether Big Five personality traits—extraversion, agreeableness, conscientiousness, openness, and negative emotionality—moderated these associations. Methods The study used a 2-week prospective longitudinal cohort design with a sample of 553 German adults (mean age 42.12, SD 12.89 years; 44.65% female) drawn from an initial sample recruited according to quotas designed to reflect the German population. Ten smartphone-sensing indicators captured 5 domains, including communication and social media app use, mobility, physical activity, environmental context, and phone-use intensity. Mental well-being was assessed using the Warwick–Edinburgh Mental Well-Being Scale, and personality was assessed using the 15-item Big Five Inventory–2 Extra-Short Form. We used multilevel latent profile analysis to identify day-level profiles nested within person-level profiles. Associations between profiles and mental well-being were tested using classification-error–adjusted mean comparisons and omnibus Wald tests. Moderation was examined using hierarchical regressions comparing models with and without profile-by-personality interactions. Results Eight day-level profiles and 7 person-level profiles were identified. Day-level profiles reflected distinct combinations of smartphone-sensing indicators. Person-level profiles represented different distributions of these daily patterns. Profiles differed significantly only in positive functioning (Wald χ ² 6 =13.39; P =.04), not in overall mental well-being, positive affect, or satisfying interpersonal relationships. The physically active and unplugged profile had higher positive functioning than the mobile and always-on social profile (mean 3.94, SD 0.63 vs mean 3.61, SD 0.74; Cohen d =0.47; 95% CI 0.21‐0.73). No other pairwise differences were significant. Sensitivity analyses excluding the smallest profile produced comparable results, supporting the robustness of the findings. Personality-by-profile interactions did not significantly improve prediction for any well-being outcome. Conclusions The findings extend the field by showing that transparent, person-centered digital phenotypes can distinguish variation in positive functioning, although causal conclusions cannot be drawn. In real-world settings, such interpretable profiles could support understandable monitoring tools and, following prospective replication and validation, inform personalized multibehavior interventions that target combinations of behaviors rather than single behaviors in isolation.

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