Additional file 1 of Serum meprin α levels for the detection of systemic inflammatory response syndrome

Le résumé fourni par la source

Supplementary Material 1. Fig. S1 Hematological and phenotypic analyses of K5Mα mice. (A) Red blood cell distribution width – coefficient of variation (RDW-CV), mean corpuscular hemoglobin concentration (MCHC) and hemoglobin concentrations (HGB) in control (n=28) and K5Mα (n=31) mice. (B) Lymphocyte, monocyte, eosinophil and basophil counts in control (n=28) and K5Mα (n=31) mice. (A+B) Median values are marked by horizontal red drawn-through lines. Reference ranges are marked by dotted lines and reference mean values by dashed lines. (C) Leukocyte proportions in the blood of K5Mα mice (n=23) and control mice (n=13). Mean ±SEM. Proportion of inflammatory monocytes within the monocyte population in the blood of K5Mα mice (n=16) and control mice (n=27). Median values are marked by horizontal red drawn-through lines. (D) Representative contour plots for the bone marrow analysis. (E) Correlation of G-CSF serum concentrations with the proportion of neutrophils in the blood of K5Mα mice (n=44). Red dashed lines mark the mean concentration and proportion detected in respective control mice. Non-linear regression (---) and respective 95% confidence band of the best-fit line (∙∙∙). (F) Superoxide (SO) and reactive oxygen species (ROS) levels in naïve purified neutrophils stimulated with serum from control (n=4) and K5Mα (n=5) mice after 30 min (SO) and 60 min (ROS). Mean ±SEM. (G) Phenotypic alterations in K5Mα mice (n=18) from day 0 to 18. Scores correlate with defined phenotype alterations as described in the Materials and Methods section. Days marked by black boxes indicate that mice had been sacrificed or died. Statistically significant differences (P<0.05) are labeled by an asterisk (*).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.