Tumor Characteristics and Survival Predictors in Patients With Colorectal Cancer: A Lebanese Single-Center Experience
Rattachement africain : lb, us, cy, Guinée. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, with incidence rates in Lebanon among the highest in the Middle East and North Africa (MENA) region. Despite this, data on CRC epidemiology, tumor characteristics, and treatment outcomes in MENA populations remain limited. This study aimed to investigate these factors, with the goal of supporting early detection, guiding clinical decision-making, and informing personalized treatment strategies. Methods: This retrospective cross-sectional study included patients diagnosed with CRC between 2019 and 2023 at the American University of Beirut Medical Center. Clinical data were retrieved from electronic health records and histopathological reports. Overall survival (OS), progression-free survival (PFS), and disease-free survival (DFS) were assessed using Kaplan-Meier survival analysis and multivariable Cox regression models. Results: A total of 349 patients (mean age 61 years) were included. Most tumors were low-grade adenocarcinomas (88.1%; n=306/347), and 73.3% (n=243/331) of patients presented with advanced-stage disease (Stages III/IV). Among patients with available MMR testing (n=181/349), 5.5% (n=10/181) were mismatch repair-deficient (dMMR) by immunohistochemistry. Molecular testing revealed KRAS mutations in 42.9% (n=70/163 tested) and BRAF mutations in 7.0% (n=9/128 tested). Smoking (HR = 2.58, p = 0.007) and age ≥65 years (HR = 1.98, p = 0.050) were associated with reduced OS. Patients with inflammatory bowel disease had a significantly increased risk of progression (HR = 9.39, p = 0.032). Left-sided tumors were associated with improved OS (HR = 0.42, p = 0.018). Conclusions: This study identifies key risk factors, including tumor location, age, IBD, and smoking, influencing survival outcomes in Lebanese patients with CRC. Findings support implementation of risk-adapted screening strategies and population-specific therapeutic approaches in Middle Eastern settings.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Tumor Characteristics and Survival Predictors in Patients With Colorectal Cancer: A Lebanese Single-Center Experience
- Date Crossref
- 01/07/2026
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Lebanese University pays non établi dans la noticeUniversité ou école supérieure
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American University of Beirut Medical Center pays non établi dans la noticeÉtablissement de santé
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American University of Beirut pays non établi dans la noticeUniversité ou école supérieure
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Brigham and Women's Hospital pays non établi dans la noticeÉtablissement de santé
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University of Nicosia pays non établi dans la noticeUniversité ou école supérieure
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Institut National de Santé Publique Guinée (code pays fourni par la source)Organisme public
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Institut National de Santé Publique pays non établi dans la noticeOrganisation à but non lucratif
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Lebanese American University pays non établi dans la noticeUniversité ou école supérieure
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Department of Clinical Epidemiology and Public Health pays non établi dans la noticeÉtablissement de santé
Lebanese University, American University of Beirut Medical Center et American University of Beirut, avec 6 autres affiliations. Pays d’affiliation : Guinée.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.