Bioactive fish-derived collagen peptides enhance cutaneous repair by reprogramming the wound microenvironment toward antioxidant, anti-inflammatory and pro-remodeling status

Le résumé fourni par la source

Chronic wounds are marked by persistent inflammation that disrupts normal tissue repair. Growing attention is being directed toward dietary supplements as non-pharmacological strategies to support wound healing. This study evaluated the therapeutic potential of a specific formulation of bioactive fish-derived collagen peptides, Naticol®, in promoting cutaneous repair. The results demonstrated that oral supplementation with Naticol® accelerated excisional wound closure in type 2 diabetic mice by restoring essential histological features of healthy skin and enhancing collagen production. This effect is achieved through the establishment of an antioxidant and anti-inflammatory wound microenvironment, the enhancement of scavenger-dependent efferocytosis, and the modulation of MMP9/TIMP1 ratio in favor of tissue remodeling. Notably, Naticol® drove transcriptional reprogramming of human dermal fibroblasts and monocytes toward antioxidant, anti-inflammatory, and pro-repair phenotypes. In human keratinocytes, Naticol® increased migratory capacity, further contributing to tissue regeneration. Consistent with in vivo findings, Naticol® treatment improved wound healing in human skin explants by reinforcing an antioxidant, anti-inflammatory, and pro-reparative microenvironment. These results highlight Naticol®, a fish-derived bioactive collagen peptide preparation, as a promising functional food component, providing an innovative complementary approach for the management of chronic wounds.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.