Green synthesis of Simarouba glauca seed-mediated silver nanoparticles: physicochemical characterization and cytotoxic mechanisms in HepG2 hepatocellular carcinoma cells

Le résumé fourni par la source

This study aims to synthesize Simarouba glauca seed-mediated silver nanoparticles (Sg-AgNPs) through an eco-friendly approach and to evaluate their antioxidant, anti-inflammatory, and anticancer efficacy against HepG2 hepatocellular carcinoma cells. To characterize biosynthesized Sg-AgNPs' optical properties, functional groups, crystallinity, morphology, particle size, and elemental composition, UV-Visible spectroscopy, FT-IR, XRD, SEM, TEM, and EDX were used. Nanoparticles exhibiting a surface plasmon resonance peak at 430 nm and TEM showing 15-60 nm spherical particles. Studies showed considerable antioxidant, anti-inflammatory, and cytotoxic actions against HepG2 cells, with an IC₅₀ value of 42.7 µg/mL. Sg-AgNPs limit cancer cell growth via oxidative stress and apoptosis. These results demonstrate Simarouba glauca-mediated AgNPs as a durable and physiologically beneficial nanoplatform for hepatocellular carcinoma therapy.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.