Figure 5 from Tumor-Associated Platelets Suppress T-cell Function and Promote Immune Evasion in TNBC via the P-selectin/P-selectin Glycoprotein Ligand 1 Pathway

Le résumé fourni par la source

Retained functionality in human CD4+ and CD8+ effector T cells exhausted by mTNBC platelets through introduction of crizanlizumab. A, Schematic of the platelet isolation and T-cell coculture experiment using platelets from healthy donors and patients with mTNBC. SF RPMI, serum-free RPMI. Flow cytometric analysis showing fold change (FC) in (B) CD4+ T-cell function, (C) CD8+ T-cell function, (D) CD4+ T-cell exhaustion, and (E) CD8+ T-cell exhaustion. For each panel, the FC is calculated relative to T cells cultured alone or relative to T cells cultured with mTNBC platelets, as indicated. Each data point represents one biological sample (n = 10 patients). FC values are normalized to the respective control (baseline = 1). Statistical significance was assessed using paired one-sample t tests and Wilcoxon signed-rank tests, as appropriate. Error bars represent mean ± SD. ns, not statistically significant; **, P < 0.01; ****, P < 0.0001.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.