Longer Asthma Duration Is Associated With Elevated Non‐ T2 Sputum Biomarkers and Reduced T2 Inflammation in Severe Asthma
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Le résumé fourni par la source
BACKGROUND: Longer asthma duration predicts non-remission in Type-2 (T2) biologic-treated severe asthma, but underlying mechanisms remain unclear. We investigated associations between asthma duration and inflammatory biomarkers that may explain differential biologic response. METHODS: We analysed cross-sectional data from adults with severe asthma in U-BIOPRED. Asthma duration was defined as years from diagnosis to study entry. T2 and non-T2 biomarkers were measured in blood and sputum. Identical assays were performed in PRISM, a validation cohort of biologic-initiators. Multivariable regression models adjusted for age, sex, ethnicity, BMI, smoking and oral corticosteroid dose. Associations between duration-related biomarkers and 12-month biologic remission were explored in PRISM. RESULTS: In U-BIOPRED (n = 411), median asthma duration was 23 years (IQR 12-38). Longer duration was associated with higher non-T2 biomarkers including sputum CXCL9 (β = 0.024, 95% CI 0.011-0.038), sputum IL-6 (β = 0.024, 95% CI 0.011-0.037) and sputum neutrophils (β = 0.009, 95% CI 0.001-0.017), but lower T2 biomarkers including plasma periostin (β = -0.006, 95% CI -0.009 to -0.003), eosinophils (blood: β = -0.002, 95% CI -0.003 to -0.001; sputum: β = -0.023, 95% CI -0.035 to -0.011), sputum EDN (β = -0.032, 95% CI -0.049 to -0.014) and FeNO (β = -0.006, 95% CI -0.010 to -0.001). PRISM (n = 474) confirmed these associations. Higher sputum CXCL9 was associated with reduced remission in anti-IL-4Rα-treated patients with asthma duration ≥ 20 years (β = -1.73, 95% CI -3.180 to -0.276). CONCLUSION: Longer asthma duration was associated with elevated airway non-T2 inflammation and reduced systemic and airway T2 inflammation. This highlights the importance of airway biomarker sampling and suggests combined T2 and non-T2 therapeutic strategies may be needed to achieve remission in long-standing asthma. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT05164939.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Longer Asthma Duration Is Associated With Elevated Non‐ <scp>T2</scp> Sputum Biomarkers and Reduced <scp>T2</scp> Inflammation in Severe Asthma
- Date Crossref
- 09/07/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guy's and St Thomas' NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Imperial College London Lung Institute pays non établi dans la noticeUniversité ou école supérieure
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Korea Environment Institute pays non établi dans la noticeUniversité ou école supérieure
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Korea National Institute of Health pays non établi dans la noticeOrganisme public
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Sysmex (Germany) pays non établi dans la noticeEntreprise
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NIHR Imperial Biomedical Research Centre pays non établi dans la noticeStructure de recherche
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Seoul National University Institute of Health and Environment pays non établi dans la noticeUniversité ou école supérieure
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University of Ulsan Department of Allergy and Clinical Immunology Asan Medical Center pays non établi dans la noticeUniversité ou école supérieure
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Royal Brompton Hospital pays non établi dans la noticeÉtablissement de santé
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D Center Europe GmbH Hamburg Germany Sysmex R& pays non établi dans la noticeEntreprise
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Department of Public Health Sciences Graduate School of Public Health pays non établi dans la noticeUniversité ou école supérieure
Guy's and St Thomas' NHS Foundation Trust, Lung Institute — Imperial College London et Korea Environment Institute, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.