Additional file 1 of Plant-derived mitochondria mitigate aging-related neurodegeneration by reprogramming microglial mitochondrial energy metabolism

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Additional file 1. Figure S1. Isolation and characterization of dietary plant-derived mitochondria (P-Mit). Figure S2. P-Mit traffic into the aged brain with blood-brain barrier permeability impairment. Figure S3. Analysis of P-Mit distribution efficiency through gut-brain axial. Figure S4. Impact of T-Mit on Morris water maze test (MWM) in mice and verification of T-Mit recipient cells with immunofluorescence assay. Figure S5. P-Mit uptake by microglia via phagocytosis. Figure S6. Correlation analysis suggests P-Mit uptake by microglia is lipid dependent. Figure S7. Mitochondrial fusion between P-Mit and mitochondria in microglia/macrophage. Figure S8. T-Mit miRNAs inhibit the expression of ND4 and ND5. Figure S9. Analysis of T-Mit curcumin and toxicity.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.