Multi-Target Neuroprotection by Syzygium aromaticum Ethyl Acetate Fraction Against Mercuric Chloride-Induced Hippocampal Toxicity: Insights from Network Pharmacology, Molecular Docking, and In Vivo Evaluation

Résumé fourni par la source

This study investigated the neuroprotective potential of the ethyl acetate fraction of Syzygium aromaticum (clove) against mercuric chloride-induced hippocampal neurotoxicity using an integrated approach combining network pharmacology, molecular docking, GC-MS phytochemical profiling, and in vivo experiments. The findings demonstrate that SEAF exerts multi-target neuroprotective effects by reducing oxidative stress, suppressing neuroinflammation, modulating neurotransmission, improving cognitive function, and preserving hippocampal neuronal architecture, highlighting its promise as a candidate nutraceutical for mitigating mercury-associated dementia risk.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.