Serum lipids, lipoproteins, oxidative stress parameters and paraoxonase 1 (PON-1) activity in post-renal transplant patients (Tx) with stable renal function and Tx patients without and with statins therapy

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Disturbances in the metabolism of the lipoproteins in post-renal transplant patients accelerate atherosclerosis and cardiovascular diseases, which are one of the major causes of death from these diseases. Serum concentration of lipid, lipoprotein, leptin, total peroxide (OxyStat), and paraoxonase-1 activity (PON1) were determined in 11 post-renal transplant patients (Tx) with stable renal function and normolipidemia, 25 Tx patients without statins therapy, 31 Tx patients with statins therapy and 53 controls. Tx patients received prednisone and Cyclosporine A or prednisone and prograf. Tx patients with stable renal function and normolipidemia had favourable clinical and laboratory parameters and lipid and lipoprotein profiles than those without statins and with statins therapy. Tx patients with dyslipidemia had disturbed lipoprotein concentration and composition, and triglyceride-rich lipoproteins (TRLs) and HDL metabolism. VLDL, IDL, LDL and HDL particles were smaller, denser and more susceptible to modification and oxidation. They were exposed to oxidative stress, and the anti-oxidative role of PON-1 was weakened. However, Tx patients with statins therapy had a lower OxyStat level and higher PON-1 basal and salt stimulation activity than Tx patients without statins therapy. We suggest that oxidative modification of HDL can affect their ability to reduce antioxidant and PON-1 activity, but statin treatment improves them, which could prevent progression of atherosclerosis and chronic allograft failure. However, future studies are required.

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