Predictive utility of computed tomography‐derived renal parenchymal volume for long‐term postoperative renal function in cats with hydronephrosis

Le résumé fourni par la source

OBJECTIVES: To evaluate the utility of preoperative feline renal parenchymal volume derived from computed tomography in predicting the serum creatinine concentration during the long-term postoperative period. MATERIALS AND METHODS: In this retrospective clinical study, we included 13 client-owned cats with normal kidneys and 24 cats with hydronephrosis (16 with chronic kidney disease and 8 without chronic kidney disease). The renal parenchymal volume was derived from CT images and normalised to the body weight. The reference intervals for renal parenchymal volume/body weight and total renal parenchymal volume/body weight were calculated from the control group. We performed between-group comparisons of the preoperative hydronephrotic renal parenchymal volume, contralateral renal parenchymal volume and total renal parenchymal volume/body weight; additionally, we analysed the relationships among hydronephrotic renal parenchymal volume/body weight, contralateral renal parenchymal volume/body weight, total renal parenchymal volume /body weight and serum creatinine concentration during the preoperative and long-term postoperative periods (>3 months). The long-term postoperative chronic kidney disease stages were classified based on the International Renal Interest Society guidelines. RESULTS: The non-chronic kidney disease subgroup had a significantly greater hydronephrotic renal parenchymal volume/body weight than the control group. The non-chronic kidney disease subgroup had a significantly greater contralateral renal parenchymal volume/body weight than the control group and the chronic kidney disease subgroup. In the non-chronic kidney disease subgroup, contralateral renal parenchymal volume/body weight showed a strong negative relationship with postoperative serum creatinine concentration (r = -0.79). In the hydronephrosis group, total renal parenchymal volume /body weight showed a moderate negative correlation with postoperative serum creatinine concentration (r = -0.46). In the non-chronic kidney disease subgroup, contralateral renal parenchymal volume/body weight was significantly greater in International Renal Interest Society stages I-II than in International Renal Interest Society stages III-IV. CLINICAL SIGNIFICANCE: The preoperative contralateral renal parenchymal volume/body weight in non-chronic kidney disease cats with hydronephrosis is associated with the long-term postoperative serum creatinine concentration. CT-based quantification of renal parenchymal volume may be useful for predicting postoperative chronic kidney disease staging based on serum creatinine concentration in cats with hydronephrosis.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.