Detergent‐Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans
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Le résumé fourni par la source
BACKGROUND: Eosinophilic esophagitis is associated with epithelial barrier dysfunction. Epidemiologic studies suggest environmental factors promote disease pathogenesis. The common household detergent sodium dodecyl sulfate (SDS) induces epithelial barrier dysfunction and eosinophilic inflammation in mice. We hypothesized that acute SDS exposure would compromise the esophageal mucosal barrier in humans. METHODS: Healthy adults brushed with 2 g of an SDS-containing toothpaste. Esophageal impedance was measured continuously pre-/post-toothbrushing to assess the effect of toothpaste on epithelial barrier function. SDS was measured in saliva using a methylene blue anionic substances assay. Participants completed 1-h esophageal string tests (ESTs) pre-/post-toothbrushing and protein isolates from EST eluates from the proximal and distal esophagus were analyzed by tandem mass tag mass spectrometry. RESULTS: Ten of twelve subjects completed the clinical study. SDS in the initial expectorate measured immediately after toothbrushing varied markedly (median: 321.40 μg/mL; range: 169.90-1243.00 μg/mL) and was detectable in saliva in 80% of subjects (median: 9.55 μg/mL; range: 0-123.40 μg/mL) at 60 min post toothbrushing. Esophageal mucosal impedance decreased within 30 min of toothbrushing (p < 0.01). Toothbrushing increased salivary viscosity and proteins associated with mucosal defense in EST eluates. The tight junction pathway was downregulated while the salivary secretion and complement and coagulation cascades pathways were upregulated in the proximal esophagus. CONCLUSION: In healthy individuals, SDS remained detectable in saliva for a prolonged period after toothbrushing at concentrations previously shown to disrupt esophageal epithelial barrier function in vitro. Toothbrushing with an SDS-containing toothpaste was associated with reduced esophageal mucosal impedance, altered salivary properties, and activated mucosal immune responses.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Detergent‐Containing Toothpaste Decreases Esophageal Mucosal Impedance and Alters Salivary Properties in Humans
- Date Crossref
- 03/07/2026
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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Phoenix Children's Hospital pays non établi dans la noticeÉtablissement de santé
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Mayo Clinic in Arizona pays non établi dans la noticeÉtablissement de santé
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Division of Allergy and Immunology Phoenix Children's Phoenix Arizona USA pays non établi dans la noticeInstitution
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Division of Pulmonology Phoenix Children's Phoenix Arizona USA pays non établi dans la noticeInstitution
Phoenix Children's Hospital, Mayo Clinic in Arizona et Division of Gastroenterology and Hepatology — Mayo Clinic, avec 8 autres affiliations.
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