Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study
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Le résumé fourni par la source
BACKGROUND: The ability of paediatric asthma scores to predict admission following initial bronchodilator therapy has not been comprehensively evaluated. METHODS: A multicentre observational study including children aged 2-18 years who received at least a single dose of bronchodilator following presentation to four Australian emergency departments (EDs). Observations were obtained by trained research nurses before and after initial treatment to calculate ten common asthma scores (Pediatric Respiratory Assessment Measure (PRAM), Siriraj Clinical Asthma Score (SiCAS), Clinical Asthma Score (CAS), Acute Asthma Intensity Research Score (AAIRS), Modified Pulmonary Index Score (MPIS), Pulmonary Index Score (PIS), Pediatric Asthma Score (PAS), Pediatric Asthma Severity Score (PASS), Woods and Downs and Pulmonary Score (WDCAS)). Primary outcome was determining the global ability of scores to discriminate between those admitted and discharged, assessed by an area under receiver operating curve (AUC ROC) ≥0.80. Secondary outcomes included adjusted ORs and the ability to provide an adequate balance between sensitivity and specificity (defined as Youden Index ≥50%). RESULTS: Of the 1238 patients enrolled, 792 (64.0%) were male, median age was 3 years (IQR 2-6), and 513 (41.4%) met the admission criteria. None of the asthma scores demonstrated an AUC ROC ≥0.80, with the four best performing (MPIS, SCAS, PIS and PAS) scoring between 0. 70 and 0.73. Results for adjusted OR analysis indicated that each one-point increase was associated with increased odds of admission for all 10 asthma scores (p=<0.001). No asthma score achieved a Youden Index ≥50%. CONCLUSION: None of the asthma scores assessed in this study met the predetermined primary outcome of an AUC ROC ≥0.80.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Diagnostic accuracy study assessing the ability of paediatric asthma scores to predict admission following initial emergency department bronchodilator therapy: a Clinical Asthma Scoring systems in Paediatric Emergency (CASPER) study
- Date Crossref
- 02/07/2026
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Flinders University pays non établi dans la noticeUniversité ou école supérieure
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Flinders Medical Centre pays non établi dans la noticeÉtablissement de santé
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Royal Children's Hospital pays non établi dans la noticeÉtablissement de santé
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The University of Melbourne pays non établi dans la noticeUniversité ou école supérieure
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Murdoch Children's Research Institute pays non établi dans la noticeOrganisation à but non lucratif
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University of Auckland Department of Surgery and Paediatrics Child and Youth Health pays non établi dans la noticeUniversité ou école supérieure
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Starship Children's Health pays non établi dans la noticeÉtablissement de santé
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The University of Western Australia Divisions of Paediatrics and Emergency Medicine pays non établi dans la noticeUniversité ou école supérieure
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Princess Margaret Hospital for Children pays non établi dans la noticeÉtablissement de santé
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Monash University Biostatistics Unit pays non établi dans la noticeUniversité ou école supérieure
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Monash Health pays non établi dans la noticeÉtablissement de santé
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College of Medicine and Public Health pays non établi dans la noticeUniversité ou école supérieure
Flinders University, Flinders Medical Centre et Royal Children's Hospital, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.