Formulation And In Vitro Evaluation of Berberine HCL Proniosomal Gel For Topical Drug Delivery

Le résumé fourni par la source

The current paper is dedicated to the development and in vitro testing of a proniosomal gel containing berberine hydrochloride to improve topical drug delivery. Berberine hydrochloride is a bioactive alkaloid that is of great antimicrobial, anti-inflammatory and wound healing effects but limited to clinical use because of poor skin absorption, retention and release, and sustained release in traditional formulations. To address these shortcomings, non-ionic surfactants (Span series), cholesterol and lecithin were used to create a proniosomal gel system through the coacervation-phase separation system. The ready-made proniosomes were added to a Carbopol gel base in order to enhance topical application. F8 had the best properties with its vesicle size measuring about 197 nm, a low polydispersity index (0.224) and encapsulation efficiency of 98.71%. The formulation exhibited appropriate physicochemical properties including skin compatible pH, ease of spread and texture. The pseudoplastic (shearthinning) was verified through rheological studies, which guaranteed ease of application. In vitro drug release experiments revealed a much longer release profile of up to 48 hours in comparison to the fast release of pure drug. The kinetic of drug release was based on a first-order reaction with the mechanism being diffusioncontrolled (Fickian). The stability studied under ICH conditions proved the stability of the formulation with slight changes in the important parameters. Generally, the designed proniosomal gel was found to be a promising carrier system to be used in topical delivery of berberine hydrochloride, as it has better permeation, long-term drug release, stability, and patient compliance than traditional formulations.

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