Accès ouvert déclaré 2026 article

Clinical features associated with Pseudomonas aeruginosa colonization in children under 2 years of age: a retrospective study of Cystic Fibrosis Registry

Ece Ocak, Güzin Cinel, Gökçen Dilşa Tuğcu, Sanem Eryılmaz Polat, Dilber Ademhan Tural, Beste Özsezen, Ebru Elmas Yalcin, Nural Ki̇per, Füsun Ünal, Hadice Selimoğlu Şen, Derya Ufuk Altıntaş, Ayşe Ayzıt Kılınç, Haluk Cezmi Çokuğraş, Hakan Yazan, Gökçen Ünal, Aslı İmran Yılmaz, İlim Irmak, Ebru Damadoğlu, Gökçen Kartal Öztürk, Esen Demir, Kemal Erdem Başaran, Ayşen Bingöl, Nihat Sapan, Yakup Canıtez, Pelin Asfuroğlu, Ayşe Tana Aslan, Koray Harmancı, Melih Hangül, Mehmet Köse, Ali Özdemir, Gizem Özcan, Nazan Çobanoğlu, Zeynep Gökçe Gayretli Aydın, Özlem Keskin, Hasan Yüksel, Şebnem Özdoğan, Erdem Topal, Gönül Çaltepe, Demet Can, Pervin Korkmaz Ekren, Mehmet Kılıç, Tuğba Şişmanlar Eyüboğlu, Sevgi Pekcan, Erkan Çakır, Nagehan Emiralioğlu, Uğur Özçelik, Deni̇z Doğru

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2Pays d’affiliation déclarés

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Le résumé fourni par la source

BACKGROUND: Respiratory colonization with Pseudomonas aeruginosa is associated with increased morbidity and mortality in cystic fibrosis (CF) patients. This study aims to assess the clinical characteristics and associated factors of CF infants under two years of age with P. aeruginosa colonization in Türkiye. METHOD: Of the 1637 patients registered in the Cystic Fibrosis Registry of Türkiye in 2019, 284 patients under two years of age were included in this retrospective cross-sectional study. Patients were classified into two groups: those with P. aeruginosa colonization (Group 1) and those without (Group 2). Cystic fibrosis transmembrane conductance regulator (CFTR) gene functions were categorized according to CFTR mutation functional class. RESULTS: Twenty-three patients (8.1%) were categorized as Group 1 and 262 participants (91.9%) were classified as Group 2. Infants with P. aeruginosa colonization (Group 1) were more likely to have minimal CFTR function compared with those without colonization (87% vs. 39.8%, p = 0.017). In addition, both Staphylococcus aureus colonization (47.8% vs. 7.3%, p < 0.001) and methicillin-resistant S. aureus positivity (17.4% vs. 6.1%, p = 0.042) were observed more commonly in Group 1. There were no statistical differences between the groups in terms of age at diagnosis, gender, mean z-scores of weight and height, newborn screening test positivity, sweat chloride test results, and pancreatic insufficiency (p > 0.05). Univariate logistic regression analysis did not identify significant associated factors for P. aeruginosa colonization. CONCLUSIONS: Our findings suggest that minimal CFTR function and S. aureus colonization are associated with P. aeruginosa colonization in CF patients under two years of age. Further studies are needed to investigate associated factors for early P. aeruginosa colonization, eradication treatment effectiveness, and longitudinal outcomes of in CF patients under two years of age.

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Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.

Titre Crossref: Clinical features associated with <i>Pseudomonas aeruginosa</i> colonization in children under 2 years of age: a retrospective study of Cystic Fibrosis Registry
Date Crossref: 30/06/2026
Éditeur: Hacettepe University Institute of Child Health
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

Ministry of Health Department of Pediatric Pulmonology pays non établi dans la notice
Organisme public
Hacettepe University pays non établi dans la notice
Université ou école supérieure
Dicle University pays non établi dans la notice
Université ou école supérieure
Cukurova University pays non établi dans la notice
Université ou école supérieure
Istanbul University-Cerrahpaşa pays non établi dans la notice
Université ou école supérieure
Bezmiâlem Vakıf Üniversitesi pays non établi dans la notice
Université ou école supérieure
Necmettin Erbakan University pays non établi dans la notice
Université ou école supérieure
Ege University pays non établi dans la notice
Université ou école supérieure
Akdeniz University pays non établi dans la notice
Université ou école supérieure
Bursa Uludağ Üni̇versi̇tesi̇ pays non établi dans la notice
Université ou école supérieure
Gazi University pays non établi dans la notice
Université ou école supérieure
Eskişehir Osmangazi University pays non établi dans la notice
Université ou école supérieure

Department of Pediatric Pulmonology — Ministry of Health, Hacettepe University et Dicle University, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

Cystic Fibrosis Research AdvancesBacterial biofilms and quorum sensingChild Nutrition and Water Access

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