Oncoplastic versus standard breast-conserving surgery for extensive ductal carcinoma in situ: a retrospective cohort study of lesions 4 cm or larger treated 1995–2018

Résumé fourni par la source

Background: The management of large-volume ductal carcinoma in situ (DCIS) is challenging, and evidence comparing standard breast-conserving surgery (S-BCS) with oncoplastic breast-conserving surgery (O-BCS) is limited. This study aimed to compare surgical and oncological outcomes of O-BCS and S-BCS in patients with large-volume DCIS treated at a single specialist breast unit.Methods: This retrospective cohort study included patients with DCIS measuring 4 cm or greater who underwent initial breast-conserving surgery (BCS) at the Nottingham Breast Institute (NBI) between 1995 and 2018. Demographic, operative, pathological, and outcome data were analysed. Primary outcomes included BCS success, margin status, re-excision, conversion to mastectomy, local recurrence, and survival. Fisher’s exact tests, independent samples t-tests, and multivariable logistic regression were used for group comparisons. Recurrence-free survival (RFS) and overall survival (OS) were evaluated using Kaplan-Meier analysis with log-rank testing.Results: A total of 139 patients were included: 94 underwent S-BCS and 45 underwent O-BCS. The mean follow-up was 6 years. O-BCS achieved a significantly higher rate of negative margins than S-BCS (73.3% vs. 23.4%, P

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.