Optimization of Tracheal Intubation and Ventilatory Management in a Rat Thoracotomy Model.
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OBJECTIVE: To establish a practical and reproducible method for procedural standardization during tracheal intubation and ventilatory management during thoracotomy in rats, and evaluate the invasiveness of thoracotomy as a control condition. METHODS: O) under open chest conditions using a macroscopic lung expansion score. In a separate experiment, the rats underwent left thoracotomy with incision lengths of 1, 2, or 3 cm, followed by macroscopic and histological assessments 4 weeks later. RESULTS: O. Macroscopic pleural adhesions and post-operative weight loss were not observed in any thoracotomy groups. Histological examination revealed mild pleural thickening and fibrin deposition without differences in incision length. CONCLUSIONS: O provides stable lung expansion during thoracotomy in rats. A thoracotomy up to 3 cm in length induces minimal pathological changes and is suitable as a control condition in experimental thoracic surgery models.
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Tokai University Hachioji Hospital Division of General Thoracic Surgery pays non établi dans la noticeÉtablissement de santé
Division of General Thoracic Surgery — Tokai University Hachioji Hospital.
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