Recent Insights into the Role of Herpesviridae in Alzheimer’s Disease: A Structured Narrative Review Based on a Systematic Literature Search
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Le résumé fourni par la source
Background/Objectives: Herpesviridae have been increasingly investigated as possible contributors to Alzheimer’s disease (AD) because of their neurotropism, lifelong latency, and capacity to modulate inflammatory and amyloid-related pathways Methods: This structured narrative review, based on a systematic literature search, examined original studies published between December 2020 and December 2025 on the association between human herpesviridae and AD. Searches were conducted in PubMed, Web of Science, and Scopus using a PRISMA-informed screening framework. Results: The available evidence was heterogeneous across viruses and study designs. HSV-1 emerged as the most consistently implicated virus, supported by epidemiological, biomarker, neuroimaging, and experimental studies, although contradictory findings were also reported. VZV was mainly associated with AD through vascular, inflammatory, and vaccination-related evidence, with several studies suggesting lower dementia risk after zoster vaccination. CMV, EBV, and HHV-6 showed biologically plausible but less consistent associations, whereas HHV-7 and HHV-8 were supported only by limited or indirect evidence. Across studies, the proposed mechanisms included chronic neuroinflammation, vascular injury, amyloid and tau dysregulation, host immune responses, and cumulative infectious burden. Conclusions: Overall, the literature suggests that the relationship between herpesviridae and AD is not uniform and that HSV-1 appears to be the most relevant candidate. However, methodological heterogeneity, possible reverse causation, and unequal study intensity across viruses limit firm conclusions. More robust longitudinal and subtype-specific studies are needed to clarify causal relevance.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Recent Insights into the Role of Herpesviridae in Alzheimer’s Disease: A Structured Narrative Review Based on a Systematic Literature Search
- Date Crossref
- 29/06/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Siena Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University of Bari Aldo Moro Section of Occupational Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ospedale Policlinico San Martino pays non établi dans la noticeÉtablissement de santé
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IRCCS Azienda Ospedaliera Metropolitana pays non établi dans la noticeÉtablissement de santé
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University of Genoa Department of Neuroscience pays non établi dans la noticeUniversité ou école supérieure
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University of Foggia Department of Medical and Surgical Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Salento Department of Experimental Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ospedale Vito Fazzi pays non établi dans la noticeÉtablissement de santé
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“Vito Fazzi” Hospital Neurology Unit pays non établi dans la noticeÉtablissement de santé
Department of Medicine — University of Siena, Section of Occupational Medicine — University of Bari Aldo Moro et Ospedale Policlinico San Martino, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.