Vitamin E administration reduces liver enzyme levels in patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD): evidence from a systematic review and meta-analysis
Rattachement africain : ua, ir, sk, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent and frequently associated with elevated liver enzymes, indicating hepatic injury. Although vitamin E has been investigated as a therapeutic antioxidant, its effects on liver enzyme levels remain inconsistent. This study aims to systematically review and quantitatively synthesize the evidence of the effects of vitamin E administration on liver enzymes in patients with MASLD. METHODS: A systematic search of scientific databases was conducted up to September 2025 to identify relevant randomized clinical trials (RCTs). Data on alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (GGT) were extracted. Pooled effect sizes were calculated as weighted mean differences (WMD) with 95% confidence intervals (CIs) using a random-effects model. RESULTS: The pooled analysis of 16 RCTs (22 effect sizes) showed that vitamin E administration significantly reduced serum liver enzyme levels in patients with MASLD, including AST (WMD: -5.94 IU/L), ALT (WMD: -7.33 IU/L), ALP (WMD: -5.68 IU/L), and GGT (WMD: -5.54 IU/L), all with statistical significance (p ≤ 0.008). Subgroup analyses revealed that longer intervention durations and higher vitamin E doses were generally associated with greater improvements in liver enzyme levels, particularly AST and ALT. In contrast, Significant reductions in ALP were mainly observed in shorter trials and with lower vitamin E doses, especially at higher doses and among obese populations. Overall, benefits were consistent across BMI categories, though effects appeared more pronounced in obese individuals. CONCLUSION: Vitamin E supplementation was associated with significant reductions in serum liver enzymes, suggesting improvement in hepatocellular injury and necroinflammatory activity in patients with MASLD. However, the available evidence is insufficient to determine its effects on fibrosis progression, metabolic burden, or long-term liver-related outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Vitamin E administration reduces liver enzyme levels in patients with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD): evidence from a systematic review and meta-analysis
- Date Crossref
- 27/06/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Bogomolets National Medical University pays non établi dans la noticeUniversité ou école supérieure
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Fasa University of Medical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Mashhad University of Medical Sciences Department of Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Comenius University Bratislava pays non établi dans la noticeUniversité ou école supérieure
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Shiraz University Department of Sport Science pays non établi dans la noticeUniversité ou école supérieure
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Islamic Azad University South Tehran Branch Department of Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Tabriz University of Medical Sciences Department of Nutrition pays non établi dans la noticeUniversité ou école supérieure
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Università degli Studi del Piemonte Orientale “Amedeo Avogadro” pays non établi dans la noticeUniversité ou école supérieure
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Semnan University Department of Physical Education and Sport Science pays non établi dans la noticeUniversité ou école supérieure
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Shahid Beheshti University of Medical Sciences Cancer Research Center pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Sport Sciences Research Institute of Iran Department of Exercise Physiology pays non établi dans la noticeStructure de recherche
Bogomolets National Medical University, Fasa University of Medical Sciences et Department of Nutrition — Mashhad University of Medical Sciences, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.