Formulation and Evaluation of Gastroretentive Bilayer Floating Tablets of Aceclofenac and Famotidine

Le résumé fourni par la source

Peptic ulcer disease results from an infection of the bacterium Helicobacter pylori. Aceclofenac is usually used to manage inflammatory disorders; however, long-term use of the drug may cause gastric irritation and ulceration. To minimize these effects on the gastric system, an attempt was made to develop a gastroretentive bilayer floating tablet of aceclofenac and famotidine and evaluate it. The bilayer tablet has an immediate release layer containing aceclofenac and a floating layer containing famotidine. By utilizing the polymers and gas-forming agents, the tablets were prepared by wet granulation. Following the success of the synthesis, preformulation studies were carried out, which included solubility, micromeritic properties and drug-excipient compatibility studies. The tablets that were previously produced were evaluated for weight variation, hardness, thickness, friability, drug content, floating behaviour and in-vitro dissolution studies. The formulated floating tablet that was developed had satisfactory physical parameters. The formulation showed good buoyancy with an acceptable floating lag time and a sustained release pattern for 10 hours. The gastroretentive bilayer tablet as per study can provide immediate analgesic action and sustained gastroprotection which can enhance patient compliance.

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