P50 sensory gating in children with ADHD, autism spectrum disorder, and neurotypicals: Within-session test-retest reliability and evaluation of methodologies

Le résumé fourni par la source

The sensory gating paradigm has gained traction in child and adolescent psychiatry for assessing sensory processing deficits. However, its test-retest reliability in pediatric clinical populations remains unclear. This study evaluated the reliability of sensory gating measures in neurotypical and clinical children. Fifty-three children (26 females, ages 8-14) participated, including neurotypical children and children with attention-deficit/hyperactivity disorder or autism spectrum disorder. Auditory P50 event-related potentials were recorded at Cz using baseline-to-peak and peak-to-peak methodology. Difference and ratio scores between paired stimuli were computed. Generalized eigendecomposition (GED) was applied as an alternative to Cz-based extraction. Reliability was assessed using intraclass correlation coefficients (ICCs). The first stimulus showed moderate-to-good reliability with both Cz and GED. The second stimulus showed poor-to-moderate reliability for Cz, but moderate-to-good for GED. Difference scores yielded moderate-to-good reliability; ratio scores showed poor-to-moderate reliability. GED produced significantly higher ICCs than Cz (mean difference = 0.15, p = 0.018). Only GED-based measures for the first stimulus consistently revealed group differences. In sum, GED enhances the test-retest reliability of P50 gating outcomes while maintaining sensitivity to group differences. Sensory gating in children can achieve reliable short-term measurements. GED offers a robust alternative to Cz-based methods, potentially improving statistical power and reliability in clinical research.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.