Non-Vigorous Physical Activity Associated with Reduced Hospitalization Risk with or without Diabetes or Peripheral Artery Disease: Study of Latinos

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PURPOSE: This study assessed whether greater physical activity (PA) and lesser sedentary behavior (SB) reduce hospitalization risk equally among those with and without prediabetes, diabetes, or peripheral artery disease (PAD). METHODS: We studied PA, SB and hospitalizations in 12,734 adults from the Hispanic Community Health Study/Study of Latinos, who were 52.2% female with mean (standard deviation) age 41.1 (14.9) yr at baseline. Participants reported 10,025 nonpregnancy-related hospitalizations (excluding emergency room only) over 13 yr. We modeled the association between accelerometer-measured activity (SB; light intensity physical activity [LPA]; moderate physical activity [MPA]; vigorous physical activity [VPA]) and hospitalization, using Andersen-Gill proportional intensity models, adjusted for demographic, lifestyle, and clinical factors. We tested whether the association differed by baseline diabetes and PAD status: normoglycemia (without diabetes or prediabetes) and no PAD, n = 4589; normoglycemia and PAD, n = 505; prediabetes and no PAD, n = 3987; prediabetes and PAD, n = 947; diabetes and no PAD, n = 1829; diabetes and PAD, n = 877. RESULTS: Greater SB and lesser LPA were significantly associated with hospitalization risk in the overall population, with intensity ratios (generalization of hazard ratio) of 1.03 (95% confidence interval 1.00, 1.05)·per h/d SB, and 0.97 (0.95, 1.00)·per h/d LPA. MPA was inversely associated with hospitalization only when comparing the second tertile to the first; intensity ratio (95% confidence interval) 0.88 (0.79, 0.98). Categorical VPA results suggest benefit in those with normoglycemia (regardless of PAD) or prediabetes with no PAD. Among those with diabetes, we observed a direct association between VPA and hospitalization in those without PAD and no association in those with PAD. CONCLUSIONS: Lower risk of hospitalization was associated with lesser SB and greater LPA, while MPA was associated with fewer hospitalizations only when performed for a duration of >8-≤22 min·d -1 .

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