ID #527 A Retrospective Analysis of BMI Z-Score and Radiotherapy-Related Adverse Events in Pediatric Central Nervous System Tumor Patients During the Peri-Radiotherapy Period

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Abstract Background This study preliminarily explores the association between peri-radiotherapy nutritional status (BMI z-score) and adverse events during radiotherapy and up to 1 month post-therapy, to inform the design of a forthcoming prospective, multicenter study focusing on the relationship between nutritional status and health-related quality of life (NCT07264023). Methods Retrospective collection of pediatric neuro-oncology patients who received radiotherapy at Guangdong Sanjiu Brain Hospital during 2023-2024. Pearson correlation was used to assess associations between BMI z-score and adverse events, with significance set at P < 0.05. Results 20 patients were included (male:female 3:1), with a median age of 10 years. A significant positive correlation was observed between pre-radiotherapy BMI z-score and adverse events during radiotherapy (r = 0.4478, P = 0.0477), and between during-radiotherapy BMI z-score and adverse events during radiotherapy (r = 0.5314, P = 0.0159). Nutritional excess was associated with a higher risk of adverse events. The correlation between post-radiotherapy BMI z-score and adverse events at 1 month did not reach statistical significance (P = 0.066) but showed a positive trend (r = 0.4189). Conclusions During the peri-radiotherapy period, BMI z-score is significantly associated with adverse events, with nutritional excess potentially increasing risk.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.