Risk Factors and Geospatial Associations With Plasmodium falciparum Malaria Infection and IgG Seroprevalence: Nigeria, 2018
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BACKGROUND: Nigeria consistently shows the greatest population burden of Plasmodium falciparum (Pf) malaria. While rapid diagnostic tests and microscopy offer valuable information for clinical decisions and prevalence estimates, serological tools provide more nuanced information on exposure history to Pf, enhancing the ability to assess and track malaria burden at a population level. METHODS: Blood samples (n=89,4328) from a nationwide 2018 HIV household survey in Nigeria were assayed for active/recent infection by testing for the Pf HRP2 and LDH antigens, and for Pf exposure by immunoglobulin G carriage against a panel of antigens. Risk factors for Pf infection and exposure were assessed using logistic regression and geospatial analyses. RESULTS: By blood antigenemia, current/recent Pf prevalence was 38.3% (95% CI: 37.2-39.5%), and seroprevalence among the panel of five Pf antigens ranged from 48% to 87%. In multivariate regression models, participants age 5-14 years had the highest odds of active infection versus children <5 years. Compared to the lowest wealth category, the wealthiest category showed a 5-fold reduction in odds of active infection, and urban living was associated with a 30% reduction. In estimating a longer window of Pf exposure, serology recapitulated these associations with [LS2.1][AJ2.2]the highest wealth category showing a 10-fold reduction, and urban living a 60% reduction, in exposure. CONCLUSIONS: Geospatial findings underscored Nigeria's hyperendemic but heterogeneous malaria epidemiology with infection and exposure are not unequally distributed among the populace. Serological data can provide greater insights into malaria risk factor analyses and augment examination of spatial heterogeneities in transmission.This is a pre-copyedited, author-produced PDF of an article accepted for publication in The Journal of Infectious Diseases following peer review. The version of record [Risk Factors and Geospatial Associations With Plasmodium falciparum Malaria Infection and IgG Seroprevalence: Nigeria, 2018. The Journal of Infectious Diseases (2026)] is available online at: https://doi.org/10.1093/infdis/jiag098. Deposited by shareyourpaper.org and openaccessbutton.org. We've taken reasonable steps to ensure this content doesn't violate copyright. However, if you think it does you can request a takedown by emailing help@openaccessbutton.org.
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