Synthesis of oleanonic acid derivatives and evaluation of their biological activities

Résumé fourni par la source

In the present study, oleanolic acid was oxidised to oleanonic acid of which different derivatives were prepared and screened for their nematicidal, antiglycation, antioxidant, urease inhibition, lung cancer (NCl-H460), oral cancer (Cal-27), HeLa cell line, NIH-3T3 cells, antibacterial, and antifungal activities. Several compounds showed strong mortality against root knot nematode (Meloidogyne incognita) at 0.125% concentration after 72 h. These compounds showed moderate to strong antiglycation activity. Potent urease inhibition activity was observed for compounds 10 and 11 (IC50 15.2, 19.5 µM, respectively).

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