Examining heterogeneity in pathways between alcohol-related factors and drinking during topiramate pharmacotherapy: A person-specific analysis
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Le résumé fourni par la source
BACKGROUND: Treatment for alcohol use disorder (AUD) is complicated by person-specific heterogeneity in factors related to AUD risk, maintenance, and recovery. To advance precision treatment, it is important to study sources of variability in the determinants of AUD treatment response. METHODS: We analyzed interactive voice response data measuring nightly drinking, desire to drink, self-efficacy to resist drinking, and drinking expectancies from two, 12-week randomized placebo-controlled trials of topiramate for drinking reduction (N = 214). World Health Organization risk drinking levels were used to measure both pre-treatment alcohol use and treatment response (i.e., reductions in risk levels). Group iterative multiple method estimation was used to determine the presence and frequency of shared versus person-specific associations between alcohol-related factors and nightly drinking. Associations between indicators of person-specific heterogeneity and pre-treatment alcohol use severity or degree of treatment response were also examined. RESULTS: Few shared pathways between alcohol-related factors and nightly drinking were observed, indicating notable person-specific heterogeneity. Nightly drinking was most often associated with same-day self-efficacy, but only for a minority (i.e., less than 20%) of the full sample. Indicators of person-specific heterogeneity were not associated with pre-treatment alcohol use severity or degree of treatment response (p > .05). CONCLUSIONS: Patterns of risk for nightly drinking during topiramate treatment may be largely person specific. More research is needed to develop approaches that target person-specific risk to optimize treatment responses for all individuals receiving pharmacotherapy for AUD.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Examining heterogeneity in pathways between alcohol-related factors and drinking during topiramate pharmacotherapy: A person-specific analysis
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The State University of New Jersey Rutgers pays non établi dans la noticeUniversité ou école supérieure
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Johnson University pays non établi dans la noticeUniversité ou école supérieure
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McLean Hospital pays non établi dans la noticeÉtablissement de santé
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University of New Mexico Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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University of Maryland Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
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University of Maryland Extension pays non établi dans la noticeUniversité ou école supérieure
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Philadelphia VA Medical Center pays non établi dans la noticeÉtablissement de santé
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University of Washington Department of Psychology pays non établi dans la noticeUniversité ou école supérieure
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University of Pennsylvania School of Medicine Department of Psychiatry pays non établi dans la noticeUniversité ou école supérieure
Rutgers — The State University of New Jersey, Johnson University et McLean Hospital, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.