Supplementary Fig. S6 from Spatial Transcriptomics Reveals Location-Specific Tumor Cell Subtypes and Signaling within Multifocal Small Intestinal Neuroendocrine Tumors

Résumé fourni par la source

Mucosal-like SI-NET cells in external datasets and heterogeneous serotonin signaling. (A) UMAP (left panels) and violin plots (right panels) showing NET cell subtypes with heterogeneous TPH1 expression in previously reported single-cell RNA-seq datasets (GSE292163) (11). Top panels, SiNET1 dataset; bottom panels, SiNET2 dataset. (B) Gene set enrichment analysis (GSEA) results of mucosal-like NET cells showing enrichment for gene sets characteristic of the ‘mucosal’ subtype. (C) KEGG pathway maps of serotonin-related signaling (hsa04726) comparing the ‘mucosal’ subtype in the current dataset with mucosal-like cells in the external dataset. Green indicates downregulated genes (log2 fold change), and red indicates upregulated genes.

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