Supplementary Figure S4 from plasmaCHORD: A Machine Learning Approach to Distinguish Clonal Hematopoiesis–Derived Variants in Liquid Biopsies from Patients with Solid Tumors

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Description of the training cohort. (A) Distribution of cancer types, stage, and patient age in the training cohort. The mean age for patients in this cohort was 65 years old (range 19-87), the most common cancer type was colorectal, and most patients had early stage disease (22 stage I, 101 stage II, 48 stage III, 53 stage IV, and 1 unknown stage). (B) Distribution of WBC only versus WBC and tumor matched sequencing and determined reference variant origin. The proportion of variants with tumor-derived reference origin is slightly higher from samples that had both WBC and tumor sequencing versus WBC sequencing alone. (C) Distribution of variants included in training cohort by gene and reference variant origin. After DNMT3A, TP53 was the second-most commonly mutated gene (98 variants) of which 67 (68%) are tumor-derived and 31 are WBC-derived.

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