Figure 5 from Pseudogene Coexpression Networks Reveal a Robust Prognostic Signature for Pediatric B-ALL Survival

Le résumé fourni par la source

RPL7P10–RPS3AP36 exhibits consistent prognostic value across cohorts. A, Time-dependent ROC–AUC values for the three most frequently selected pseudogene interactions in both TARGET (triangles) and MP2PRT (circles) cohorts. RPL7P10–RPS3AP36 consistently maintains AUC > 0.5 at all time points. B and C, Risk stratification in TARGET based on the edge weight of RPL7P10–RPS3AP36. B, Expression relationship between RPL7P10 and RPS3AP36 in high-risk, low-risk, and normal bone marrow groups. Gene expression values are shown as normalized counts, as defined by the normalization pipeline for network inference described in Methods. C, The corresponding Kaplan–Meier curve for OS. D and E, Equivalent analysis in MP2PRT using projected data into the TARGET coexpression space. The edge weight stratifies patients into high- and low-risk groups with significant survival differences, recapitulating the patterns observed in TARGET.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.