Accès ouvert déclaré
2026
article
Association and risk prediction of 19 complex diseases with polygenic scores and socioeconomic status
Fiona A. Hagenbeek, Anne Richmond, Max Tamlander, Kira E. Detrois, Zhiyu Yang, Tuomo Hartonen, Daniel L. McCartney, FinnGen, Aarno Palotie, Mark Daly, Bridget Riley-Gills, Howard Jacob, Coralie Viollet, Slavé Petrovski, Alix Berton, Santha Ramakrishnan, Ellen Tsai, Zhihao Ding, Emily Holzinger, Robert Plenge, J. Maranville, Mark McCarthy, Rion Pendergrass, Jonathan Davitte, Chia-Yen Chen, Melis A. Aksit, Anna Vlahiotis, Katherine Klinger, Clement Chatelain, Jörg Blankenstein, Karol Estrada, Robert Graham, Dawn Waterworth, Chris O´Donnell, Nicole Renaud, Tomi P. Mäkelä, Jaakko Kaprio, Minna Ruddock, Lila Kallio, Antti Hakanen, Terhi Kilpi, Markus Perola, Jukka Partanen, Taneli Raivio, Eero Punkka, Teija Kekonen, Raisa Serpi, Kati Kristiansson, Sanna Siltanen, Veli-Matti Kosma, Arto Mannermaa, Jari Laukkanen, Tiina Jokela, M. Ahlroth, Johanna Mäkelä, Outi Tuovila, Jeffrey Waring, Fedik Rahimov, Ioanna Tachmazidou, Marc Jung, Hanati Tuoken, Shameek Biswas, Benjamin Sun, Neha Raghavan, Jae-Hoon Sul, Xinli Hu, Ma ́en Obeidat, Jonathan Chung, Jonas Zierer, Mari Niemi, Johanna Schleutker, Tiina Wahlfors, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Katriina Aalto‐Setälä, Mika Kähönen, Hanna Kujala, Triin Laisk, Natalia Pujol, Veikko Salomaa, Jaana Suvisaari, Satu Koskela, Jouni Lauronen, Kristiina Aittomäki, Pirkko Pussinen, Tuomo Meretoja, Heikki Joensuu, Peeter Karihtala, Emma Juuri, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Fredrik Åberg, Daniel Gordin, Patrik Finne, Joni A. Turunen, Minna Raivio, Pentti Tienari, Martti Färkkilâ, Jukka Koskela, Sampsa Pikkarainen, Kari Eklund, Paula Kauppi, Juha Sinisalo, Marja‐Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Johanna Mattson, Eveliina Salminen, Terhi Ollila, Katariina Hannula-Jouppi, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Erkki Isometsä, Antti Aarnisalo, Ilkka Immonen, Salla Ranta, Filip Scheperjans, Felix Vaura, Esa Pitkänen, Hannele Laivuori, Tuomo Kiiskinen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Hanna Ollila, Elmo Saarentaus, Anne Kerola, Eero Vuoksimaa, Joni Lindbohm, Matthew Sampson, Michelle McNulty, Aoxing Liu, Joel Rämö, Austin Argentieri, Amanda Elliott, Elisa Rahikkala, Kirsi Sipilä, Valtteri Julkunen, Ville Leinonen, Sanna Toppila-Salmi, Mikko Hiltunen, Eino Solje, Hannu Kankaanranta, Antti Mäkitie, Iiris Hovatta, Niko Välimäki, Minttu Marttila, Anne Portaankorva, Eija Laakkonen, Heidi Silven, Eeva Sliz, Riikka Arffman, Susanna Savukoski, Riitta Kaarteenaho, Minna Karjalainen, Jaakko Tyrmi, Laura Kuusalo, Laura Pirilä, Tapio Hellman, Matti Vuori, Teemu Niiranen, Timo Blomster, Johanna Huhtakangas, Terttu Harju, Kaisa Tasanen, Laura Huilaja, Vuokko Anttonen, Marja Vääräsmäki, Outi Uimari, Laure Morin‐Papunen, Maarit Niinimäki, Terhi Piltonen, Reetta Kälviäinen, Hilkka Soininen, Mikko Kiviniemi, Oili Kaipiainen-Seppänen, Margit Pelkonen, Päivi Auvinen, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Kai Kaarniranta, Jukka Peltola, Airi Jussila, Katri Kaukinen, Pia Isomäki, Jussi Hernesniemi, Annika Auranen, Hannu Uusitalo, Teea Salmi, Venla Kurra, Laura Kotaniemi‐Talonen, Argyro Bizaki-Vallaskangas, Juha Rinne, Roosa Kallionpää, Markku Voutilainen, Antti Palomäki, Riitta Lahesmaa, Kaj Metsärinne, Jenni Aittokallio, Klaus Elenius, Sirkku Peltonen, Leena Koulu, Ulvi Gursoy, Varpu Jokimaa, Tytti Willberg, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Apinya Lertratanakul, Relja Popovic, Mengzhen Liu, Anneke Den Hollander, Jan Freudenberg, Britney Milkovich, Andrew Blumenfeld, Tushar Kumar, Dirk Paul, Bram Prins, Eleanor Wheeler, Kousik Kundu, Santosh Atanur, Andrew Lowe, Thomas Spargo, Oliver Burren, Margarete Fabre, Fabio Baschiera, Hans van Leeuwen, Himanshu Manchanda, Karl Heilbron, Martin Rao, Nicole Schmidt, Samu Kurki, Johanna Mielke, Juho Immonen, Thomas Battram, Tobias Hogrebe, Susan Eaton, Ketian Yu, Stephanie Loomis, Coro Paisan-Ruiz, Elke Markert, Frank Li, Yao Hu, Christoph Ogris, Eric Simon, Julio Cesar Bolivar Lopez, Monika Frysz, Marla Hochfeld, Cara Carty, Michael Turchin, Neelakshi Jog, Corneliu Bodea, Janie Shelton, Chen; id_orcid 0000-0001-6249-8957 LI, Kritika Singh, Peng Jiang, Elena Sanchez, Lilith Moss, Zijie Zhao, Anna Podgornaia, Natalie Bowers, Edmond Teng, Tim Lu, Hubert Chen, Jennifer Schutzman, Erich Strauss, Hao Chen (5190), David Choy, Brian Yaspan, Cameron Adams, Michael Rothenberg, Sergio Dellepiane, Anubha Mahajan, Michael Holmes, Diana Chang, Tushar Bhangale, Fanli Xu, Laura Addis, John Eicher, Linda McCarthy, Jorge Esparza Gordillo, Joanna Betts, Rajashree Mishra, Audrey Chu, Diptee Kulkarni, Janet Kumar, Charli Harlow, Lea Sarow-Blat, Diana L. Cousminer, Jagtar Nijjar, Jessica Chao, Michal Magid, Shashank Jariwala, C. Douglas Floyd, Dan Swerdlow, Erding Hu, Prerak Desai, Stephen Haddad, Damien Croteau-Chonka, Billy Fahy, Paola Bronson, Kirsi Auro, David Pulford, Sauli Vuoti, Dermot Reilly, Karen He, Ekaterina Khramtsova, Amy Hart, Meijian Guan, Alessandro Porello, P. Dunnmon, Sara Gale, Brice Keyes, John Kwon, Jonathan Sherlock, Matt Loza, Chris Whelan, W. Galpern, Yanfei Zhang, Mona Selej, Abolfazl Doostparast Torshizi, Qingqin S. Li, Sahar Mozzafari, Christopher Deboever, Jason Miller, Fabiana Farias, Andrey Loboda, Jorge Del-Aguila, Elisabeth Vollmann, József Kármán, Julie Fiore, Rajesh Kamath, Andrei Popescu, Delphine Fagegaltier, Travis Barr, Aristide Merola, Oliver Freeman, Simonne Longerich, Enrico Ferrero, Nikos Patsopoulos, Nancy Finkel, Sabina Pfister, Shola Richards, Katherine McCauley, Xiaobo Xia, Mike Mendelson, Majd Mouded, Debby Ngo, Kirsi Kalpala, Melissa Miller, Nan Bing, Jaakko Parkkinen, Heli Lehtonen, Stefan McDonough, Ying Wu, Erin Macdonald-Dunlop, Jessica Chung, Michael McLean, Joshua Chiou, Hye Jin Kim, Sivakumar Pitchumani, Sumedha Jassal, Madhurima Saxena, Catherine O’Riordan, Samuel Lessard, Suzanne Jacobs, Hamid Mattoo, David Habiel, Guanling Huan, Anu Jalanko, Risto Kajanne, Mervi Aavikko, Helen Cooper, Denise Öller, Tarja Laitinen, Rodos Rodosthenous, Sofia Kuitunen, Mitja Kurki, Juha Karjalainen, Pietro Della Briotta Parolo, Arto Lehisto, Juha Mehtonen, Reza Jabal, Mutaamba Maasha, Sanni Ruotsalainen, Samuel Jones, Raymond Walters, Paavo Häppölä, Topi Paavilainen, L. Elisa Lahtela, Johanna Paltta, Juulia Partanen, Olli Pietiläinen, Veera Timonen, Mari Kaunisto, Elina Kilpeläinen, Tianduanyi Wang, Timo P. Sipilä, Oluwaseun Alexander Dada, Awaisa Ghazal, Rigbe Weldatsadik, Jaska Uimonen, Kati Donner, Anu Loukola, Päivi Laiho, Susanna Lemmelä, Teemu Paajanen, Arto Pietilä, Aki Havulinna, Auli Toivola, Kristina Zguro, Mary Pat Reeve, Shanmukha Sampath Padmanabhuni, Harri Siirtola, Javier Gracia-Tabuenca, Marika Kaakinen, Shuang Luo, Vincent Llorens, Dawit Yohannes, Iina Laak, Pauli Wihuri, Tom Southerington, Meri Lähteenmäki, Riccardo E. Marioni, Pekka Martikainen, Nina Mars, Andrea Ganna, Samuli Ripatti
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Résumé fourni par la source
BACKGROUND: Differences in disease risk are linked to inherited genetic variation and social circumstances, but how these factors jointly relate to multiple diseases is not fully understood. This study investigates the independent and combined associations of genetic predisposition and socioeconomic status with common diseases. METHODS: We analyzed data from 743,194 adults from three biobank studies in Finland and the United Kingdom, including European and non-European ancestry individuals. Genetic predisposition was measured using polygenic scores for 19 common diseases. Socioeconomic status was assessed through education and occupation. We evaluated associations of genetic and socioeconomic factors with disease risk and whether genetic associations differed across education levels. Models including both genetic and educational factors were compared with models including only one factor and models including their interaction. RESULTS: Here, we show that both genetic predisposition and socioeconomic status are associated with disease risk across most conditions. For seven diseases, genetic associations are stronger in highly educated groups, while occupation shows smaller differences. Patterns are generally consistent across ancestry groups, though education associations are less stable in non-European individuals. While both education and polygenic scores independently improved prediction, combining both provided additional modest improvement to prediction for 16 and 12 out of 19 diseases in FinnGen and the UK Biobank, respectively. CONCLUSIONS: Genetic variation and social circumstances are linked to differences in disease risk both independently, and in combination with one another. Considering both factors modestly improves identification of higher-risk groups and highlights the value of accounting for social context alongside inherited variation in population-level assessments.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Association and risk prediction of 19 complex diseases with polygenic scores and socioeconomic status
- Date Crossref
- 11/06/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
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