Development and Evaluation of an Oral Herbal Suspension of Stigma maydis Extract for Antioxidant and Antiurolithiatic Activity

Le résumé fourni par la source

Plant-based preparations made up of phytocomplexes derived from phytoconstituents present in plant extracts have been extensively explored for treating oxidative stress and renal diseases because of the possible benefits that can be gained from them and reduced side effects. The plant Stigma maydis, which has antioxidant and antiurolithiatic actions, is associated with the presence of phenols and flavonoids. The current study was designed to synthesize and assess the oral herbal suspension consisting of Stigma maydis extract and examine its physicochemical properties, antioxidant capacity, antiurolithiatic action, release profile, and stability. The herbal suspension was prepared using Stigma maydis extract with the use of xanthan gum and sodium CMC as suspending agents, Tween-80 as wetting agent, sorbitol as sweetening agent, and sodium benzoate as preservative. The formulation was subjected to evaluation tests for organoleptic parameters, pH, viscosity, settling volume, redispersibility, particle size analysis, FTIR compatibility test, and DSC thermographic study. DPPH radical scavenging activity test and calcium oxalate crystallization inhibition test were performed for the determination of antioxidant and antiurolithiatic activity, respectively. The formulation of the oral suspension of Stigma maydis was found to possess good physicochemical stability, controlled drug release, marked antioxidant properties, and antiurolithiatic efficacy. The oral suspension was found to be stable under accelerated testing conditions and could potentially be considered as an herbal formulation for the treatment of renal diseases due to oxidative stress.

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