Endovascular ablation of the right greater splanchnic nerve for the management of heart failure with preserved ejection fraction: a systematic review and meta-analysis
Rattachement africain : us, Égypte, ps, iq, jo, Soudan, ae. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) remains difficult to manage because conventional therapies often provide limited symptom relief and do not adequately address exercise-related congestion. Right greater splanchnic nerve (GSN) ablation has emerged as a potential therapeutic approach by modulating splanchnic venous capacitance. However, current evidence is limited and includes both uncontrolled and randomized studies. METHODS: We performed a systematic review and meta-analysis of studies evaluating right GSN ablation in HFpEF. Searches were conducted in PubMed, Scopus, and Embase in December 2024. Randomized and non-randomized studies were included. Continuous outcomes were pooled as mean differences (MDs) with 95% confidence intervals (CIs). Sensitivity analyses excluding the randomized controlled trial (RCT) were performed for selected outcomes. Analyses based on uncontrolled studies and converted median/interquartile range data were considered exploratory. RESULTS: The most consistent findings were observed in functional and exercise-related hemodynamic outcomes. Six-minute walk distance improved at both 6 and 12 months, and KCCQ overall score showed improvement, although with substantial heterogeneity. Provocative hemodynamic measures, including 20 W and peak pulmonary capillary wedge pressure, were reduced at 1 month, whereas resting hemodynamic measures showed no clear pooled benefit. NT-proBNP, renal indices, blood pressure, heart rate, and left ventricular ejection fraction were largely unchanged. Overall, randomized sham-controlled evidence did not demonstrate a clear comparative benefit. CONCLUSIONS: Right GSN ablation may improve selected exercise-related hemodynamic, functional, and patient-reported outcomes in HFpEF, but the current evidence base is driven mainly by small uncontrolled studies. Randomized evidence remains neutral, and further sham-controlled trials are required.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Endovascular ablation of the right greater splanchnic nerve for the management of heart failure with preserved ejection fraction: a systematic review and meta-analysis
- Date Crossref
- 08/06/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Jamestown pays non établi dans la noticeUniversité ou école supérieure
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Cairo University Cairo University, Égypte (code pays fourni par la source)Université ou école supérieure
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An-Najah National University pays non établi dans la noticeUniversité ou école supérieure
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Palestine Polytechnic University pays non établi dans la noticeUniversité ou école supérieure
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University of Baghdad pays non établi dans la noticeUniversité ou école supérieure
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Baghdad Medical City pays non établi dans la noticeÉtablissement de santé
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University of Jordan pays non établi dans la noticeUniversité ou école supérieure
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Zagazig University Zagazig University, Égypte (code pays fourni par la source)Université ou école supérieure
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University of Khartoum University of Khartoum, Soudan (code pays fourni par la source)Université ou école supérieure
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Dubai Medical College pays non établi dans la noticeUniversité ou école supérieure
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University of Kerbala pays non établi dans la noticeUniversité ou école supérieure
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University of Warith Al-Anbiyaa pays non établi dans la noticeUniversité ou école supérieure
University of Jamestown, Cairo University (Cairo University, Égypte) et An-Najah National University, avec 9 autres affiliations. Pays d’affiliation : Égypte, Soudan.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.