Sex differences in the association between bone mineral density and lipid profiles in people with type 2 diabetes in southwest China
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Le résumé fourni par la source
Aims To explore the relationship between bone mineral density (BMD) and lipid levels among different genders in people with type 2 diabetes (T2D) across Southwest China, potentially providing a reference for future risk stratification research on osteoporosis in this population. Methods Clinical data from 355 people with T2D admitted to Xinqiao Hospital between January 2015 and December 2020 were retrospectively analyzed. The correlation among serum lipid levels and BMD in people with T2D of distinct genders were investigated. Results Subgroup analysis revealed a significant interactive effect of sex on the lipid and BMD. Regarding lipid profiles, serum triglyceride (TG) and apolipoprotein E (ApoE) concentrations showed positive correlations with left femoral neck BMD in men with T2D (r = 0.139, r = 0.146, p < 0.05, respectively), and serum lipoprotein-a and ApoE levels were positively correlated with spinal BMD in women with T2D (r = 0.178, p < 0.05; r = 0.231, p < 0.01, respectively). Furthermore, serum high-density lipoprotein (HDL) levels demonstrated a significant positive correlation with serum 25-hydroxyvitamin D concentrations in women with T2D (r = 0.345, p < 0.01). Multivariate logistic regression analysis revealed that serum calcium levels serve as a protective predictor of osteoporosis in men with T2D ( p < 0.05). Conversely, apolipoprotein A1 emerged as an independent risk factor for osteoporosis in women with T2D ( p < 0.05). Conclusion In men with T2D, appropriate TG levels were positively associated with bone mass (femoral neck BMD). Among women with T2D, HDL levels were negatively associated with osteoporosis-related markers. ApoE levels are positively correlated with BMD in both sexes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Sex differences in the association between bone mineral density and lipid profiles in people with type 2 diabetes in southwest China
- Date Crossref
- 01/09/2026
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Army Medical University Department of Endocrinology pays non établi dans la noticeUniversité ou école supérieure
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Dalian Medical University pays non établi dans la noticeUniversité ou école supérieure
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Second Affiliated Hospital of Chongqing Medical University pays non établi dans la noticeÉtablissement de santé
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Chongqing Medical University pays non établi dans la noticeUniversité ou école supérieure
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Xinqiao Hospital pays non établi dans la noticeÉtablissement de santé
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Army (Third Military) Medical University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
Department of Endocrinology — Army Medical University, Dalian Medical University et Second Affiliated Hospital of Chongqing Medical University, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.