Mitigating the Impact of MR Sequence Parameters: Increasing the Robustness of DL‐Based Cortical Thickness Estimates

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ABSTRACT Cortical thickness measurements from MRI are increasingly used as biomarkers for neurodegenerative disease progression. However, variations in MRI acquisition parameters, such as inversion time (TI) and repetition time (TR), which are common in clinical settings, can compromise the reliability and sensitivity of these measurements. We fine‐tuned a deep‐learning‐based segmentation tool (DL+DiReCT) to reduce its dependence to image contrast variations by training it on simulated MPRAGE images derived from quantitative relaxation maps. Fine‐tuning markedly reduced contrast sensitivity, with the Pearson correlation coefficient decreasing from to . Evaluation on a synthetic atrophy dataset demonstrated that our model accurately replicated atrophy trends with minimal underestimation, outperforming FreeSurfer and SynthSeg. When applied to a dataset of relapsing–remitting multiple sclerosis (RRMS) patients, the fine‐tuned model showed a substantial reduction in contrast sensitivity and maintained stable performance after controlling for covariates such as age, sex, field strength, and Expanded Disability Status Scale (EDSS) score. Overall, the proposed approach achieves robust contrast invariance without sacrificing sensitivity to cortical atrophy, offering a practical improvement for longitudinal and multi‐center clinical studies.

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