Comprehensive multi-omics pan-cancer analysis revealed that ANTXR1 is a potential biomarker for diagnosis and immunotherapy
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Le résumé fourni par la source
BACKGROUND: Anthrax toxin receptor 1 (ANTXR1, TEM8) has been implicated in tumor angiogenesis and progression, yet its pan-cancer immunological role remains incompletely defined. METHODS: We conducted an integrative pan-cancer analysis using multi-omics and clinical data from TCGA, GTEx, and public databases to evaluate the expression, prognostic and diagnostic value, genomic features, immune associations, and drug sensitivity of ANTXR1. Single-cell and spatial transcriptomic analyses were performed to define its cellular and spatial distribution. Functional roles were validated in gastric cancer (GC) using in vitro and in vivo models. RESULTS: ANTXR1 was aberrantly expressed across multiple tumor types and significantly associated with tumor stage and unfavorable prognosis, particularly in GC. Diagnostic analyses demonstrated high accuracy of ANTXR1 in several malignancies. Elevated ANTXR1 expression correlated with genomic instability, stromal enrichment, M2 macrophage infiltration, and reduced CD8⁺ T cell abundance, indicating an immunosuppressive tumor microenvironment. Single-cell and spatial analyses identified fibroblasts as the primary source of ANTXR1 with co-localization to extracellular matrix components. Functionally, ANTXR1 knockdown suppressed GC cells proliferation, migration, invasion, and tumor growth, inhibited M2 macrophage polarization, and enhanced CD8⁺ T cell activity, partly through PI3K/AKT pathway inhibition. CONCLUSION: ANTXR1 functions as a stromal-associated immunomodulatory driver of tumor progression and immune suppression, representing a promising biomarker and therapeutic target in stromal-rich cancers.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comprehensive multi-omics pan-cancer analysis revealed that ANTXR1 is a potential biomarker for diagnosis and immunotherapy
- Date Crossref
- 06/06/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangxi Medical University Department of Gastrointestinal Surgery pays non établi dans la noticeUniversité ou école supérieure
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Guangxi Zhuang Autonomous Region Department of Education pays non établi dans la noticeOrganisme public
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Guangxi Zhuang Autonomous Region Health and Family Planning pays non établi dans la noticeOrganisme public
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First Affiliated Hospital of GuangXi Medical University pays non établi dans la noticeÉtablissement de santé
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Guangxi Clinical Research Center for Enhanced Recovery After Surgery pays non établi dans la noticeStructure de recherche
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Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer pays non établi dans la noticeStructure de recherche
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Guangxi Zhuang Autonomous Region Engineering Research Center for Artificial Intelligence Analysis of Multimodal Tumor Images pays non établi dans la noticeStructure de recherche
Department of Gastrointestinal Surgery — Guangxi Medical University, Guangxi Zhuang Autonomous Region Department of Education et Guangxi Zhuang Autonomous Region Health and Family Planning, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.