Ligature-induced periodontitis exacerbates high-carbohydrate/high-fat diet-induced fatty liver in mice under non-diabetic conditions

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Abstract Background Recent studies have suggested that periodontitis affects non-alcoholic fatty liver disease (NAFLD). Until now, the underlying mechanisms have mainly been investigated in the context of diabetes, which is a risk factor for NAFLD. However, clinical research indicates that 80% of NAFLD patients do not have diabetes, with a complication rate of 40% even in advanced cases. In this study, we investigated whether periodontitis exacerbates NAFLD under non-diabetic conditions using a high-carbohydrate/high-fat diet (HCHFD). Methods We first developed non-diabetic NAFLD mice induced by an HCHFD and then analyzed the effect of ligature-induced periodontitis in an established NAFLD mouse model. Mice were fed a normal chow (NC), an HCHFD, or a high-fat diet (HFD), a commonly used diet in previous NAFLD studies for 6 weeks. Results HCHFD induced hepatic steatosis without causing glucose intolerance or insulin resistance, whereas a HFD showed glucose intolerance accompanied by hepatic steatosis. Ligature-induced periodontitis facilitated HCD-induced steatosis and caused interlobular fibrosis in the liver. Conclusion A non-diabetic mouse model for NAFLD, closer to the clinical presentation than pre-existing mouse models, indicated that ligature-induced periodontitis exacerbated non-diabetic NAFLD, which accounts for the majority of the NAFLD population.

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