Accès ouvert déclaré
2026
article
Low-Dose Rivaroxaban and Cardiovascular Events in Advanced Kidney Disease
S V Badve, Sunil V. Badve, Vlado Perkovic, Vivekanand Jha, Raja Ramachandran, Lily Mushahar, Jan Menne, An S. De Vriese, Patrick Rossignol, Adrien Flahault, Maha Al Ammari, Habib Skhiri, Michael Walsh, David Collister, Adrian Liew, Laurent Billot, Séverine Bompoint, Anthony Devaux, Min Jun, Enmoore Lin, Aline Ramos da Cruz, Jeffrey T. Ha, John W. Eikelboom, Ahmed Shaman, Meg J. Jardine, Shilpanjali Jesudason, Muh Geot Wong, Craig S. Anderson, Amit X. Garg, Hiddo J. L. Heerspink, Helen Monaghan, Anushka Patel, Patrick B. Mark, David C. Wheeler, Li Zuo, Li Zuo, Helen Pilmore, Martin Gallagher, TRACK Trial Investigators, S Badve, Jeffrey Ha, Meg Jardine, Shilpa Jesudason, Amit Garg, Hiddo Heerspink, Patrick Mark, David Wheeler, Jicheng Lv, Glenn Chertow, Kenneth Mahaffy, Kimberly Walters, David Johnson, Clare Arnott, Monica Badve, Amanda Hugman, Lubomyr Lemech, Freda Passam, Amanda Siriwardana, Wing Yeung, Alexandra Gallagher, Daniel O'Hara, Stéphane Zuily, Sébastien Richard, Jessica Sun, Hans Van Der Meersch, Hans Lorenzen, Manuela Armenis, Arlen Wilcox, Sedricx Fontanilla, Alison Coenen, Martyn Ralph, Namrata Kumar, Hong Man, Annie Gao, Abhijit Parshionikar, Nursafwana Zulkhernain, Krupa Philip, Brooke Livingston, Rob Mina, Jenny Landrigan, Marouane Daki, Carlyn Quek, Jane Troup, Bijini Bahuleyan, Andria Yaourtis, Jonathan Mendoza, Kousthubha Madhusudan, Shalomi Weerawardena, Michelle Kim, Ewelina Czajkowska, Colette Beck, Shreya Jyo, Wai Poon, Aishwarya Nair, Mallikarjuna Kunigari, Rajendra Kumar, Gunjan Tripathi, Bhavani Siddeshi, Susheel Chintapandu, Luc Frimat, Julie Lecomte, Nancy Hamilton, Marie-Lauren Antoine, Taous Zamoun, Khaoula Bouhmaida, Lila Zakour, Lisa Djema, Grégory Moulin, Ons Bouzrara, Quentin Gérome, Priscillia Morel, Khizra Sultana, Fatimah Ehnidi, Badriyah Somali, Roa Bamaie, Brendan Smyth, Amanda Varghese, Franziska Pettit, Ivor Katz, Chenlei-Kelly Li, Kim Giyeon, Saiyini Pirabhahar, Tamison Waghorn, Brendon Neuen, Bruce Cooper, Lauren Heath, Jeffery Ha, Elaine Phua, Amanda Matthews, Yan Li, Helen Clayton, Rebecca Stevenson, Anna Tam, Diana Ngau, Alison Vo, Mary-Rose Birch, Jacquline PEARCE, Debbie Knagge, Jenny Chen, Jane Holt, Hicham Hassan, Yulan Shen, Michelle De Giorgio, Bhadran Bose, Murali Komala, Nikki Wong, Junie McCourt, Kenneth Yong, Grant Luxton, Jong Do Kim, Nga Cheng, Shobha Castelino, Zuzana Gray, Michelle Glasel, Stuti Kumar, Randall Faull, R. Carroll, Bronwyn Hockley, Meg Hockley, Jenny Latte, Girish Talaulikar, Geetha Raman, Giles Walters, Mary Bodilsen, Andrea Blanco, Adam Flavell, Eugenia Pedagogos, Kate Robson, Nelson Craig, Levidiotis Vicki, Ava Bachari, Shannon Kokoszka, Jing Lei, Jeremy Frazier, Dharmenaan Palamuthusingam, Daniel Ahrens, Amanda Elms, Karina Murphy, Asha Skaria, Mital Vaidya, Cindy Ong, Amanda Collings, Alex Ingram, An Vriese, Isabel Moyaert, Lislot Mommerency, Lonnie Pyne, Christian Rabbat, Matthew Lanktree, Taylor Donders, Andrea Vieira, Dorothy Walsh, Stephanie Thompson, Nandini Basuray, Rocio Romero, Andrea Echeagaray, Valentin Panisset, Alice Corbel, Anne Diata, Hélène Coyard, A. Pezzi, Nicolas Peters, Nathalie Pierrez, Francois Chantrel, Rocsana Fickl, Camille Alzina, Marie Ramstein, H Sissoko, Margaux Vo-Dinth, Yves Dimitrov, Jean-Pierre Daessle, Manon Hassold, Agnès Roesslinger, Clothilde Muller, Marc Bouiller, Clément Dumond, Julie Gros, Isabelle Kaze, Florine Hardy, O. Guérin, Benoit Schwartz, Clément Maho, Timothée Nussbaumer, Farideth Alenabi, Valérie Simonklein, Yannick Meur, I. Ségalen, Morgane Gosselin, Lucas Lanfranco, Catherine Hanotel, Christelle Guillerm-Regost, Bénédicte Sautenet, Christelle Barbet, Olivier Olivier, Vincent Esnault, Sandor Vido, Nadia Rowlan, Kévin Zorzi, Fitsum Gebre-Egziabher, Vladimir Coliche, Maité Daroux, Anthony Ducrocq, Stéphane Burtey, Alexandre Klein, C. Becmeur, Imen Maghrebi, Xavier Bassand, Adèle Hechinger, Sandrine Muller, Farideh Alenabi, Marie Heitz, Mehadji Maaz, Valérie Betz, Sabine Camara-Perrin, Elina Haerrel, Lavinia Ezechieli, Ebru Akcivan, Huelya Oktas, Arun Prabhahar, Jyoita Bharati, Thakur Sain, Deepak Kumar, Rishabh Tiwari, Manisha Sahay, Rakesh Sahay, Dr SREE BHUSHAN RAJU, Nikhilesh Kumar, Atanu Pal, Jharna Mandal, Vinay Rathore, Prachita Joshi, Shankar Prasad, Ravindra A, Srinivas Shenoy, Ganesh P, Sreedharan Nair, Ramaswami Sethuraman, Amarneni Chowdary, Sadish Kona, Sashidhar Chennamsetty, Sadish Konar, Suresh Sankar, Balaraman V, Avinash Ignatius, Umapati Hegde, Dhara lalkiya, Saurabh Nayak, Aman Anand, Sanjay Sharma, Jennifer Deepak, Subba Rao, Sandeep Garg, Navjeet Malik, Srikanth Gundlapalli, Jalluri Alice, Tushar Sontakke, Manish Balwani, Suchita Dudhabade, Sourabh Sharma, Anshul Kushwaha, Vivek Ruhela, Mamta Kumari, M. Pinaki, Baishali B, Sadip Panda, Kiran Samal, Maheswaran Kalimuthu, Subasni Govindan, Magdalene Mayappan, Nur Yahya, Engku Safruddin, Nur Faishal, Abdul Gafor, Muhammad Shamsi, Theepa Nesam, Wan Daud, Ahmad Rahim, Fong Ken, Lim Yee, Nur Kazmin, Noor Mustafa, Noorul Rosman, Arbaiyah Bain, RAHIMAH ISMAIL, Lim Kun, Lee Wan, Gan Chung, Albert Hing, Nur Arzmi, Sridhar Ramanaidu, Loh Loong, Thong Mean, Lee Yan, Suria Junus, Low Wen, Muneswaran Chandaran, Norlia Khairi, Umi Kassim, Laily Sulaiman, Umi Jamil, Aisyah Shadzili, Sarannia Thanganathan, Noorsyamimi Akhir, Sadanah Mazlan, Durga Arimuthu, Syahida Hadi, Khairul Muhamad, Noraini Othman, Nor Nordin, Chan Sia, Harold Hilarion, Jennifer Rejohn, Alecia Fat, Carolyn Li, Anita Manocha, 冷淦, Stephenie Albart, Teoh Tat, Chong May, Norshahida Hamid, Mohd Jamil, Vimala Kasinathan, Loh Chuan, Ching Hua, Mohammad Asmee, Ku Razi, Tham Duan, Ong Chen, Siti Aris, Mohamad Mustafa, Wan Hassan, Suhaidarwani Hamid, Muhammad Abdullah, Mohd Yusoff, Rihan Saari, Low Cee, Noor Awang, Siti Rani, Nuzaimin Ahmad, Го Линь, Nur Abidin, Norizan Ibrahim, Cheng Fatt, Lau Sian, Mohd Mamat, Nur Has, Fatin Giman, Raudhah Hakbar, Norazinizah Miswan, Wong Mun, Murugaiah Nadesan, Norfarahin Hisham, Fauziah Llah, Wan Rozali, Dibya Shah, Mukunda Kafle, Mahesh Sigdel, Ratna Gajurel, Santa Das, Rabin Nepali, Midhan Shreshtha, Akritee Pokhrel, Jeny Acharya, Evan Malla, Samina Basent, Jharana Thapa, Omprakash Das, Salah Abdelwahab, Ahmed Elsoul, Ali Almalki, Shatha Alhalwan, Muath Alawlah, Salem Harbi, Noon Mohamed, Muhammad Khan, Roba Hejazi, Magdi Alla, Dina Alyamwabi, Maha Ammari, Mohammed Tawhari, Abid Khan, Abrar Musattat, Osama Nuwair, Bashaer Alqurashi, Laila Sadagah, Ahmad Makeen, Haneen Alzahrani, Omnia Fallatah, Rehab Albakr, Abdullah Alhammad, Rasha Sulaiman, Abeer Alshareef, Rasil Hadi, Moudi Alwehaibi, Weng Wanting, Khoo Benjamin, Lim Rosa, Lin Yan, Azyan Alyas, Jonathan Hao, Tan Grace, Lim Kuang, Su Jialei, Lim Khim, Siti Adnan, Lu Min, Yuh-Mou Sue, Yen-Cheng Chen, Chung-Yi Cheng, Chung-Te Liu, Yu-Chieh Wu, Ching-Ya Tzeng, Hsiu-Chen Chang, Szu-Chun Hung, Ko‐Lin Kuo, Ting-Yun Lin, Ching‐Hsiu Peng, Yi-Chun Wang, Che‐Hsiung Wu, Juan-Ling Huang, Yee-Yung Ng, Tze-Wah Kao, Jana Tao, Hsaio-Wei Ku, Yu-Shan (Susan) Huang, Tzu-Tsung Chien, Cheng‐Hao Weng, Kuan‐Hsing Chen, Ching-Wei Hsu, Wen‐Hung Huang, Ya-Chung Tian, Tsung‐Yu Tsai, Yu-Syuan Huang, Yi-Wen Chiu, Hung-Chun Chen, Jer-Ming Chang, Chi‐Chih Hung, Shang-Jyh Hwang, Hung‐Tien Kuo, Mei-Chuan Kuo, Jia‐Jung Lee, Lee‐Moay Lim, Ping-Hsun Wu, Li‐Yun Chang, Jer-Chia Tsai, Shu-An Yang, Hung-Ju Lu, Horng-Rong Chang, Tung‐Wei Hung, Jong-Da Lian, Po-Yu Tsai, Sheng-Wen Wu, Ellie (Chia-Lun) Chang, Nouha Mahmoud, A. Letaief, Faouzi Haouala, Meriem Salem, Manel Salah, M. Hamouda, Sabra Aloui, Ines Jaafer, D. Zellama, Raja Boukadida, Yosra Guedri, Senda Mrabet, Asma Fradi, Mohamed Hmida, Hanen Abid, K. Kammoun, I. Agrebi, B. Fendri, Mohamed Zouaghi, Hiba Ghabi, I. Mami, Jannet Laabidi, Dalel Touati, Anis Baffoun, Fethi Hamida, S. Chargui, Sahar Aguerbi, Mariem Harzallah, H. Kâaroud, Semia Barbouch, Rim Goucha, M. Jerbi, Sarra Hadded, Meriam Khadhar, Raja Aouidia, Hanen Gaied, Zohra Ati, Amel Ayed, Amel Chouk, A. Hadhri, Rachid Jaballah
3Citations signalées — pas une note de qualité
43Institutions déclarées
16Pays d’affiliation déclarés
Résumé fourni par la source
Importance: Approximately 10% to 15% of patients with advanced chronic kidney disease (CKD) experience a fatal or nonfatal cardiovascular event annually. The effects of antithrombotic therapies on cardiovascular events in patients with advanced CKD are unknown. Objective: To determine whether low-dose rivaroxaban reduces rates of adverse cardiovascular events compared with placebo in patients with advanced CKD. Design, Setting, and Participants: Randomized, double-blind, placebo-controlled trial conducted at 90 centers in 12 countries. Eligible participants were adults with CKD stage 4 or 5 and patients with dialysis-dependent kidney failure. Participants had a history of either coronary artery disease; nonhemorrhagic, nonlacunar stroke; peripheral artery disease; diabetes; or were 65 years or older. Enrollment occurred between January 2021 and July 2025. The trial was stopped early on August 7, 2025, for lack of efficacy. Final follow-up occurred on October 30, 2025. Statistical analyses were conducted in February and March 2026. Interventions: Patients were randomized 1:1 to receive rivaroxaban 2.5 mg twice daily or placebo. Main Outcomes and Measures: The primary outcome was a composite of cardiovascular death, nonfatal myocardial infarction, stroke, or a peripheral artery disease event. The primary safety outcome was major bleeding. Results: Of 1458 randomized patients (mean [SD] age, 63.2 [11.6] years, 432 [29.6%] female), 1360 (93.3%) completed follow-up. During a median follow-up of 1.7 years, the primary outcome occurred in 164 patients (22.6%) in the low-dose rivaroxaban group and 151 (20.7%) in the placebo group (13.0 vs 11.8 events per 100 person-years; hazard ratio, 1.09 [95% CI, 0.87-1.36]; P = .46). Major bleeding occurred in 64 patients (8.8%) receiving low-dose rivaroxaban and 44 (6.0%) receiving placebo (5.1 vs 3.4 events per 100 person-years; hazard ratio, 1.51 [95% CI, 1.02-2.22]; P = .04). Conclusions and Relevance: In patients with advanced CKD at high cardiovascular risk, low-dose rivaroxaban did not reduce the risk of a composite cardiovascular outcome. Major bleeding rates were significantly higher in the low-dose rivaroxaban group compared with the placebo group. Trial Registration: ClinicalTrials.gov Identifier: NCT03969953.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Low-Dose Rivaroxaban and Cardiovascular Events in Advanced Kidney Disease
- Date Crossref
- 28/07/2026
- Éditeur
- American Medical Association (AMA)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Atrial Fibrillation Management and OutcomesAcute Kidney Injury ResearchChronic Kidney Disease and Diabetes