Investigating the Mechanism of Magnesium Uptake in Lactobacillus rhamnosus

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Introduction: Magnesium is essential for human health, playing a critical role in over 300 enzymatic reactions, including protein synthesis, blood pressure regulation, and muscle and nerve function. Probiotics, beneficial microorganisms in the human gut, were recently associated with mineral metabolism. Despite extensive research on both magnesium and probiotics, the interaction and synergistic effects between magnesium supplementation and probiotic efficacy remain insufficiently explored. Aims: Our primary goal was to explore the role of Lactobacillus rhamnosus as a potential magnesium internalizer. This enhances our understanding of how bacteria influence magnesium bioaccessibility and contribute to human mineral homeostasis. Materials and Methods: Using MgSO₄ as a magnesium source, we assessed the bacteria's ability to uptake and internalize magnesium. L. rhamnosus cultures were grown in media supplemented with MgSO₄ at varying concentrations to determine the optimal conditions for magnesium uptake. Results: Electron Microscopy provided insights into surface morphology and revealed detailed internal cellular structures, such as cell wall integrity and intracellular accumulation. By comparing structural differences between cells grown with and without MgSO₄, we aimed to elucidate how magnesium influences the physical and structural properties of L. rhamnosus and evaluate its capacity for magnesium uptake and internalization. Conclusion: Our findings indicate that L. rhamnosus can effectively uptake magnesium, with visible changes in cell structure observed. This study contributes to a deeper understanding of the interplay between magnesium and probiotics within the context of nutribiotics, paving the way for improved dietary supplements and therapeutic strategies.

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