GALLBLADDER SMALL CELLS NEUROENDOCRINE CARCINOMA AND HODGKIN LYMPHOMA IN A HIV-PATIENT: CASE REPORT

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All articles of this category (opens in new window) Case Presentation: Female patient, 55 years old, former alcoholic, former smoker, obese, diagnosed with HIV for 4 years and using antiretroviral therapy. In 2015 she was diagnosed with Hodgkin's Lymphoma. One year after the completion of chemotherapy, systemic revaluation with total abdominal tomography showed cholelithiasis. Cholecystectomy performed. Anatomopathological examination showed undifferentiated malignant neoplasia affecting the entire wall thickness, with presence of perineural infiltration. Radial, proximal and cystic duct surgical limits compromised. Immunohistochemistry has been shown to be a gallbladder small cells neuroendocrine carcinoma. Staging evaluation of T3N0M0. Liver segmentectomy, extrahepatic bile duct resection and hepatic hilum lymphadenectomy were performed. Surgical limits and lymph nodes free. Patient evolved well postoperatively, and maintains regular outpatient follow-up, with no evidence of local recurrence or metastasis. Discussion: Gallbladder cancer is an uncommon but high mortality pathology. The most common histological type is adenocarcinoma. In the reported case, the patient, on the other hand, had one of the rarest histological types, the small cell neuroendocrine tumor, which is characterized by very aggressive progress. It is more common to be diagnosed in women from the sixth decade of life and often accompanying cholelithiasis. At diagnosis, the tumor is usually at a more advanced stage. Due to the scarce literature, there is no consensus on the treatment of this type of tumor. For localized tumors, cholecystectomy and sometimes hepatic segmentectomy are usually performed. Final comments: Our case demonstrates the importance of cancer screening in patients with important antecedents. The HIV-infected and obese patient developed Hodgkin's lymphoma and gallbladder neuroendocrine tumor. Despite important comorbidities and the presence of an aggressive tumor, the case patient presented an uncomplicated postoperative course. This case generates a reflection about the approach of tumors in patients with antecedents, which may have favorable outcomes. Publication History Article published online: 23 October 2019 © 2019. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/) Thieme Revinter Publicações Ltda. Rua do Matoso 170, Rio de Janeiro, RJ, CEP 20270-135, Brazil Bibliographical Record Carolina Matté Dagostini, Murillo Cesar Gionedis, Giovani Schulte Farina, Mariana Gabriela Mandelli, Rafael Fontana. GALLBLADDER SMALL CELLS NEUROENDOCRINE CARCINOMA AND HODGKIN LYMPHOMA IN A HIV-PATIENT: CASE REPORT. Brazilian Journal of Oncology 2019; 15. DOI: 10.1055/s-0044-1797773

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