Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adolescents: results from the cross-sectional observational EAGLE study
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Le résumé fourni par la source
Objective We describe physical distancing behaviors to avoid coronavirus disease 2019 (COVID-19) and their associations with health-related quality of life (HRQoL) and related outcomes, among immunocompromised adolescents (aged 13–17 years). Methods EAGLE was a cross-sectional, observational study of immunocompromised adults, adolescents, and children in the United States and United Kingdom. Adolescents and their caregivers were enrolled between February and June 2023 and completed a web-based survey that was designed to capture the following outcomes: physical distancing behaviors in the past 4 weeks, measured using the Physical Distancing Scale for COVID-19 Avoidance (PDS-C19®); HRQoL (Pediatric Quality of Life Inventory™ [PedsQL™] Generic Core Scales); loneliness (Direct Measure of Loneliness [DMOL] scale); health-state utility (EQ-5D-5L); mental health (Hospital Anxiety and Depression Scale; HADS®); and school and activity impairment (Work Productivity and Activity Impairment plus Classroom Impairment Questions: Specific Health Problem questionnaire; WPAI-CIQ:SHP). Results Among 405 immunocompromised adolescents, the PDS-C19 mean T-score was 49.1, indicative of moderate physical distancing intensity. Most participants reported moderate (60.1%) or high/very high (16.3%) physical distancing intensity; fewer reported low (10.0%) or very low (13.7%) physical distancing intensity. The PedsQL™ Generic Core Scales mean total score was 58.0 (scale range: 0–100, where higher scores indicate better HRQoL). Most outcomes moderately correlated with PDS-C19 (| r | = 0.4–0.5), with stronger correlations (| r |>0.6) shown for WPAI-CIQ:SHP activity impairment, school presenteeism, and overall school impairment. Linear regression models adjusting for confounders showed similar associations. Conclusions Two years after national lockdowns ended, most immunocompromised adolescents practiced moderate-to-high intensities of physical distancing to avoid COVID-19. Higher intensities of physical distancing were associated with worse HRQoL and greater school and activity impairment, emphasizing the prolonged burden of COVID-19 avoidance in this population.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Assessing the association of physical distancing to avoid COVID-19 with health-related quality of life in immunocompromised adolescents: results from the cross-sectional observational EAGLE study
- Date Crossref
- 28/05/2026
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
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AstraZeneca (Switzerland), AstraZeneca (Italy) et Clinical Research Services, avec 9 autres affiliations.
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